CD Markers
CD17 / CDw17



Topic Completed: 1 December 2013

Revised: 13 December 2018, last major update December 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD17, CDw17, Lactosylceramide[title]
Page views in 2018: 177
Page views in 2019 to date: 54
Cite this page: Pernick N. CD17 / CDw17. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd17.html. Accessed March 24th, 2019.
Definition / general
  • Most abundant glycosphingolipid in neutrophils; NOT a protein
  • Also known as lactosylceramide
  • "CD17" is also a type of mutation in beta-thalassemia, unrelated to CD markers (Fetal Diagn Ther 2010;27:25)
Pathophysiology
Clinical features
  • Elevated levels are present in plasma of patients with familial hypercholesterolemia, and in plaque intima of aorta in patients who died of cardiovascular disease (Proc Natl Acad Sci U S A 2004;101:6490)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Granulocytes, macrophages / monocytes, platelets, basophils, CD19+ B cells and tonsillar dendritic cells
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