CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 Janaury 2016, last major update February 2002

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD171 or L1
Cite this page: CD171. website. Accessed October 24th, 2016.
Definition / General
  • Aka L1
  • Adhesion molecule required for normal neurohistogenesis
  • Mutations cause CRASH (Corpus callosum hypoplasia/agenesis, Retardation, Aphasia, Spastic paraplegia/shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
  • May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, co-stimulation of T-cell activation in vitro
Positive Staining - Normal
  • Post-mitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes