Cite this page: CD171. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd171.html. Accessed October 24th, 2016.
Definition / General
- Aka L1
- Adhesion molecule required for normal neurohistogenesis
- Mutations cause CRASH (Corpus callosum hypoplasia/agenesis, Retardation, Aphasia, Spastic paraplegia/shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
- May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, co-stimulation of T-cell activation in vitro
Positive Staining - Normal
- Post-mitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes