CD Markers
CD175


Topic Completed: 1 February 2002

Minor changes: 14 December 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: CD175 [title] or Tn [title]

Nat Pernick, M.D.
Page views in 2019: 35
Page views in 2020 to date: 6
Cite this page: Pernick N. CD175. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd175.html. Accessed August 13th, 2020.
Definition / general
  • CD175:
    • Aka Tn
    • Simple mucin-type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
  • CD175s:
    • Aka Sialyl Tn (STN)
    • Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
    • Presence associated with aggressive tumors
    • High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
    • Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease
  • CD175s: carcinoma
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