CD Markers
CD175
Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: CD175 [title] or Tn [title]
CD175
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 14 December 2019
Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: CD175 [title] or Tn [title]
Cite this page: Pernick N. CD175. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd175.html. Accessed August 13th, 2020.
Definition / general
- CD175:
- Aka Tn
- Simple mucin-type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
- CD175s:
- Aka Sialyl Tn (STN)
- Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
- Presence associated with aggressive tumors
- High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
- Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease
- CD175s: carcinoma
