CD Markers
CD178

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update August 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD178
Definition / General
  • Aka CD95 ligand, Fas ligand (FasL)
  • Important role in T cell mediated cytotoxicity; induces apoptosis in Fas-expressing target cells
  • Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas-expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
  • May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
  • Fas-FasL binding triggers apoptosis in lymphocytes
  • Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
  • Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
Positive Staining - Normal
  • Activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
Positive staining - Tumors