CD Markers

Topic Completed: 01 February 2014

Revised: 13 December 2018, last major update February 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CD19[title]
Cite this page: Pernick N. CD19. website. Accessed December 15th, 2018.
Definition / general
  • Common B cell marker (also CD20, CD79a, PAX5)
  • Expressed by B cells and follicular dendritic cells
  • Early B lineage-restricted antigen present on most pre-B cells, B-ALL and B-CLL cells (OMIM #107265)
Diagrams / tables

Images hosted on other servers:

CD19 structure and signaling

Clinical features
  • Defects in CD19 cause immunodeficiency common variable type 3 (OMIM #613493), characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen
  • CD19 count may be useful to screen for B cell lymphoproliferative disorders (Clin Chem Lab Med 2011;49:115)
  • Adoptive transfer of anti-CD19-chimeric antigen receptor-expressing T cells may be effective for B cell malignancies (Blood 2010;116:4099, Sci Transl Med 2013;5:177, Blood 2013;122:4129)
Uses by pathologists
Flow cytometry images

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Follicular lymphoma with IgG light chain restriction (C-F)

Biphenotypic acute leukemia with CD19 and myeloperoxidase coexpression (fig B)

Hairy cell leukemia variant

Positive staining - normal
  • Pre-B cells, B cells; follicular dendritic cells
  • Hematogones in bone marrow by flow cytometry
Positive staining - disease
Negative staining