CD Markers
CD19

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 December 2015, last major update February 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD19[title]
General
  • Common B cell marker (also CD20, CD79a, PAX5)
  • Expressed by B cells and follicular dendritic cells
  • Early B lineage-restricted antigen present on most pre-B cells, B-ALL and B-CLL cells (OMIM #107265)
Pathophysiology
Diagrams / Tables

CD19 structure and signalling

Clinical Features
  • Defects in CD19 cause immunodeficiency common variable type 3 (OMIM #613493), characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen
  • CD19 count may be useful to screen for B cell lymphoproliferative disorders (Clin Chem Lab Med 2011;49:115)
  • Adoptive transfer of anti-CD19-chimeric antigen receptor-expressing T cells may be effective for B cell malignancies (Blood 2010;116:4099, Sci Transl Med 2013;5:177, Blood 2013;122:4129)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Tonsil (normal)

Various images

Flow Cytometry Images

Images hosted on other servers:

Follicular lymphoma with IgG light chain restriction (C-F)

Biphenotypic acute leukemia with CD19 and myeloperoxidase coexpression (fig B)

Hairy cell leukemia variant

Positive Staining - Normal
  • Pre B cells, B cells; follicular dendritic cells
  • Hematogones in bone marrow by flow cytometry
Positive Staining - Disease
Negative Staining