CD Markers

Topic Completed: 1 July 2013

Minor changes: 19 June 2019

Revised: 13 December 2018, last major update July 2013

Copyright: (c) 2002-2018,, Inc.

Related: CD1aCD1cCD1dCD1eCD1-General

Nat Pernick, M.D.
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Cite this page: Pernick N. CD1b. website. Accessed August 14th, 2020.
Definition / general
  • On chromosome 1q22-23 (not MHC linked); noncovalently associated with beta2 microglobulin
  • Capable of binding ligands with greatly varying alkyl chain lengths (including Mycobacteria tuberculosis and Mycobacteria leprae) through a complex network of interconnected hydrophobic pockets (J Immunol 2004;172:2382, Proc Natl Acad Sci USA 2011;108:19335, OMIM #188360)
  • Part of immune response to intracellular bacteria
  • Human gammadelta T cells recognize Lipid A in a CD1b or CD1c restricted manner as a first response to gram negative bacteria (Biol Direct 2009;4:47)
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

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Leprosy patient

Positive staining - normal
  • Cortical thymocytes, Langerhans cells (weaker staining than CD1a), myeloid dendritic cells, brain pyramidal cells and subpopulation of B cells
Positive staining - disease
Negative staining
  • Normal B cells
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