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Table of Contents
Definition / General | Diagrams / Tables | Uses by Pathologists | Micro Images | Positive Staining - Normal | Positive Staining - Disease | Negative StainingDefinition / General
- On chromosome 1q22-23 (not MHC linked); non-covalently associated with beta2 microglobulin
- Capable of binding ligands with greatly varying alkyl chain lengths (including Mycobacteria tuberculosis and Mycobacteria leprae) through a complex network of interconnected hydrophobic pockets (J Immunol 2004;172:2382, Proc Natl Acad Sci USA 2011;108:19335, OMIM #188360)
- Part of immune response to intracellular bacteria
- Human gammadelta T cells recognize Lipid A in a CD1b or CD1c restricted manner as a first response to gram negative bacteria (Biol Direct 2009;4:47)
Diagrams / Tables
Image hosted on Nature.com:
MHC class I-related lipid-binding proteins
Uses by Pathologists
- No significant clinical use by pathologists
Micro Images
Images hosted on other servers:
Leprosy patient
Thymus tissue
Urinary bladder shows strong cytoplasmic
positivity in urothelial cells
Positive Staining - Normal
- Cortical thymocytes, Langerhans cells (weaker staining than CD1a), myeloid dendritic cells, brain pyramidal cells and subpopulation of B cells
Positive Staining - Disease
- Dendritic cells in mycosis fungoides (J Cutan Pathol 1995;22:223), myeloid leukemia, some B and T cell malignancies
- Monocytes of most sickle cell anemia patients (Hum Immunol 2004;65:1370)
Negative Staining
- Normal B cells
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