CD Markers
CD1c

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update July 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

Related: CD1aCD1bCD1dCD1eCD1-General

Definition / General
  • On chromosome 1q22-23 (not MHC linked); non-covalently associated with beta2 microglobulin
  • Mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells (Immunity 2010;33:853)
  • Has the capacity to present a wide repertoire of antigens to reactive T cells (Mol Immunol 2013;55:182, J Biol Chem 2011;286:37692)
  • Expressed on a subset of myeloid dendritic cells; secrete IL10 in response to Escherichia coli (Eur J Immunol 2012;42:1512)
  • Common CD1c antibody is BDCA1
Clinical Features
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

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Skin: dermal dendritic cells

Spleen: marginal zone B cells

Stomach: H. pylori+ mucosa

Thyroid gland

Immature dendritic cells

Adenocarcinoma: left-ovary, right-endometrium


Images hosted on Nature.com:

Skin: dermal dendritic cells (fig c)

Positive Staining - Normal
  • Cortical thymocytes, Langerhans cells (weaker staining than CD1a), immature myeloid dendritic cells (J Clin Invest 2007;117:2517)
  • Subset of normal peripheral B cells, subset of activated T cells
Positive Staining - Disease
Negative Staining
  • Normal B cells
Electron Microscopy Description
Electron Microscopy Images

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Found in various cellular locations