CD Markers
CD1d




Topic Completed: 1 July 2013

Revised: 13 December 2018, last major update July 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

Related: CD1aCD1bCD1cCD1eCD1-General
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Cite this page: Pernick N. CD1d. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd1d.html. Accessed May 22nd, 2019.
Definition / general
  • CD1d presents lipid antigens to natural killer T (NKT) cells; when activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon gamma and IL4 (Wikipedia: CD1D [Accessed 31 July 2018], OMIM: 188410 [Accessed 31 July 2018])
  • B cells also present lipid antigen to CD1d restricted invariant NKT cells, which contributes to maintaining tolerance in autoimmunity
  • On chromosome 1q22-23 (not MHC linked)
  • Also called R3G1
  • Sole group 2 member of the CD1 family of MHC-like glycoproteins
Diagrams / tables

Images hosted on other servers:

Antigen presentation

Viral evasion of antigen presentation

Intestinal epithelial CD1d expression

Clinical features
Uses by pathologists
Case reports
  • 6 year old boy with no apparent immunodeficiency who suffered severe life-threatening infection with varicella vaccine virus, with low invariant natural killer T cells and diminished CD1d expression (J Infect Dis 2011;204:1893)
Microscopic (histologic) images

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Cervix: HPV associated lesions

Lymph node: paracortical dendritic cells (fig 2)

Placenta: trophoblast

Skin: scalp

Positive staining - normal
Positive staining - disease
  • Some B and T cell malignancies; keratinocytes in psoriasis
Negative staining
  • Normal B cells
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