CD Markers
CD2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update August 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

Related: CD2R

Definition / General
  • Early T cell marker expressed on all peripheral blood T cells, 95% of thymocytes (OMIM #186990), NK cells (J Biol Chem 2010;285:41755), but no B cells
  • Gene is at 1p13.1; protein is member of immunoglobulin superfamily
Terminology
  • Also called E rosette receptor, because CD2 antibodies inhibit formation of rosettes with sheep erythrocytes
  • Also called LFA2 (leukocyte function antigen), T11
Pathophysiology
  • Binds CD58 (LFA3) on antigen-presenting cells, which enables T cells to respond to lower concentrations of antigen (J Exp Med 1999;190:1383)
  • Mediates adhesion between T cells and antigen presenting cells, induces costimulatory signals in T cells and T cell cytokine production, inhibits apoptosis of activated peripheral T cells (Immunology 2013;139:48)
  • Regulates T cell anergy
  • Regulates T and NK-mediated cytolysis
  • CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions (J Immunol 2009;182:6815); CD2(low) plasmacytoid dendritic cells are depleted in HIV+ patients (Cell Mol Immunol 2011;8:441)
  • CD2 promotes NK cell membrane nanotube formation (PLoS One 2012;7:e47664)
Diagrams / Tables

Image hosted on other servers:

T cells and antigen presenting cells

Clinical Features
Uses by Pathologists
  • T cell marker (membranous staining), although CD3 is more commonly used
  • Marker of systemic mastocytosis
Micro Images

Images hosted on other servers:

Bone marrow:
angioimmunoblastic
T celllymphoma
(fig A: weak staining)

Liver biopsy: hepatosplenic T-cell lymphoma (fig b)

Lymph node:
hydroavacciniforme-like
lymphoma (fig E)

Lymph node: anaplastic large cell lymphoma


Images hosted on Nature.com:

Lymph node: Hodgkin lymphoma (fig a)

Positive Staining - Normal
  • Thymocytes (95%), mature peripheral T cells (almost all), NK cells (80-90%), mast cells
  • Variable thymic B cells (50%), Langerhans cells
Positive Staining - Disease
Negative Staining