General
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• Binds protein C in a calcium-dependent manner
• Aka Endothelial Protein C Receptor (EPC R), protein C receptor
• Protein C is a vitamin K dependent enzyme with major role in coagulation of blood; activated when thrombin binds to thrombomodulin on endothelium.
• Mutations in CD201 and thrombomodulin associated with late fetal loss; similar mutation associated with venous thromboembolism and myocardial infarction

Positive staining (normal)
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• Endothelial cells (not in liver and kidney)

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