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General
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Physiology
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Clinical features
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Uses by pathologists
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Micro images
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CD21+ normal germinal center



Follicular dendritic cell sarcoma:

Duodenum

Liver (figure 2B)

Lymph node

Mediastinum

Oral cavity (fig A)

Spine (figure 3A)

Tonsil




Follicular lymphoma:

Well organized clusters of dendritic cells in testicular tumor (fig C)



Other tumors:

Nodal marginal zone B cell lymphoma

Littoral cell angioma of
spleen (CD21+ lining cells)


Lymph node: nodular lymphocyte predominant Hodgkin lymphoma;
CD21 highlights follicular dendritic cell networks within nodules


Positive staining - normal
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Positive staining - disease
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Negative staining
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End of CD Markers > CD21



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