CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 September 2018, last major update May 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CD22[title]

Cite this page: Pernick, N. CD22. website. Accessed September 25th, 2018.
Definition / general
  • Also called B lymphocyte cell adhesion molecule (BL-CAM), Sialic acid binding immunoglobulin-like lectin / Siglec-2
Clinical features
Uses by pathologists
  • Pan B cell marker; helpful for diagnosis of hairy cell leukemia
  • Aberrant CD22 expression is useful to detect monoclonal B cells of CLL admixed with benign polyclonal B cells (Am J Clin Pathol 2005;123:826)
Microscopic (histologic) images

Images hosted on other servers:

High grade B cell lymphoma, fig F

B ALL, fig D

Burkitt lymphoma, fig D

Normal tonsil

Positive staining - normal
  • B cells (considered a pan B cell antigen), dendritic cells and basophils
Positive staining - disease
Negative staining