CD Markers
CD22

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 December 2015, last major update May 2014

Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.

PubMed Search: CD22[title]

Definition / General
Terminology
  • Also called B lymphocyte cell adhesion molecule (BL-CAM), Sialic acid binding immunoglobulin-like lectin / Siglec-2
Pathophysiology
Clinical Features
Uses by Pathologists
  • Pan B cell marker; helpful for diagnosis of hairy cell leukemia
  • Aberrant CD22 expression is useful to detect monoclonal B cells of CLL admixed with benign polyclonal B cells (Am J Clin Pathol 2005;123:826)
Micro Images

Images hosted on other servers:

High grade B cell lymphoma, fig F

B-ALL, fig D

Burkitt lymphoma, fig D


Normal tonsil

Positive Staining - Normal
  • B cells (considered a pan B cell antigen), dendritic cells and basophils
Positive Staining - Disease
Negative Staining