Table of ContentsDefinition / general
Cite this page: Pernick N. CD221. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd221.html. Accessed July 21st, 2019.
Definition / general
- Aka insulin-like growth factor 1 receptor
- Mediates insulin stimulated DNA synthesis and IGF1 stimulated cell proliferation and differentiation
- Often overexpressed in malignant tissue, where it functions as an anti-apoptotic agent by enhancing cell survival