CD Markers

Topic Completed: 1 December 2014

Revised: 21 June 2016, last major update December 2014

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD223 or Lymphocyte-Activation Gene 3 (LAG-3)

Nat Pernick, M.D.
Page views in 2019: 59
Page views in 2020 to date: 43
Cite this page: Pernick N. CD223. website. Accessed August 13th, 2020.
Definition / general
  • Aka Lymphocyte-Activation Gene 3 (LAG-3)
  • Homologous to CD4
  • Associates with MHC class II molecules on monocytes/dendritic cells, which are subsequently activated
  • May help activated CD4+ and CD8+ T cells to fully activate monocytes and dendritic cells, leading to optimized MHC class I and class II T cell responses
Positive staining - normal
  • Activated T cells, activated NK cells
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