Cite this page: Pernick N. CD223. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd223.html. Accessed August 13th, 2020.
Definition / general
- Aka Lymphocyte-Activation Gene 3 (LAG-3)
- Homologous to CD4
- Associates with MHC class II molecules on monocytes/dendritic cells, which are subsequently activated
- May help activated CD4+ and CD8+ T cells to fully activate monocytes and dendritic cells, leading to optimized MHC class I and class II T cell responses
Positive staining - normal
- Activated T cells, activated NK cells