CD Markers
CD230

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 Janaury 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD230 or prion protein [title]
Definition / General
  • Aka prion protein (“PRotein INfectious agent”)
  • Mutations associated with Gerstmann-Straussler disease, Creutzfeldt-Jakob disease (CJD), familial fatal insomnia, which are neurodegenerative conditions transmissible by inoculation or inherited as autosomal dominant disorders
  • Aberrant isoforms can act as an infectious agent in these disorders as well as in kuru and in scrapie in sheep
  • Replication (infectivity) occurs as abnormal protein with conformational change recruits cellular prion and converts it into infective form with same conformational change
Positive Staining - Normal
  • Neurons (nonpathogenic isoform)
Additional References