CD Markers

Topic Completed: 1 August 2013

Revised: 19 December 2018, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: CD233

Nat Pernick, M.D.
Page views in 2019: 86
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Cite this page: Pernick N. CD233. website. Accessed August 13th, 2020.
Definition / general
  • Aka band 3
  • Erythrocyte membrane protein that functions as an anion (chloride/bicarbonate) exchanger and attachment site for cytoskeleton (where spectrin/actin bind to membrane lipid bilayer)
  • Truncated form of CD233 is expressed in kidney and involved in acid secretion
  • Mutations cause hereditary spherocytosis or distal renal tubular acidosis (due to defective acid secretion)
  • Other mutations cause novel blood group antigens which form the Diego blood group system
  • Southeast Asian ovalocytosis is due to heterozygous deletions, common where Plasmodium falciparum malaria is endemic, associated with abnormally rigid, stomatocytic erythrocytes, asymptomatic; children are protected against cerebral malaria
Positive staining - normal
  • Erythrocyte plasma membrane (strong), basolateral membrane of a-intercalated cells of the distal tubules and collecting ducts of the kidney
Negative staining
  • All other cells
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