Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 22 August 2013, last major update February 2002
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD233
- Aka band 3
- Erythrocyte membrane protein that functions as an anion (chloride/bicarbonate) exchanger and attachment site for cytoskeleton (where spectrin/actin bind to membrane lipid bilayer)
- Truncated form of CD233 is expressed in kidney and involved in acid secretion
- Mutations cause hereditary spherocytosis or distal renal tubular acidosis (due to defective acid secretion)
- Other mutations cause novel blood group antigens which form the Diego blood group system
- Southeast Asian ovalocytosis is due to heterozygous deletions, common where Plasmodium falciparum malaria is endemic, associated with abnormally rigid, stomatocytic erythrocytes, asymptomatic; children are protected against cerebral malaria
Positive staining (normal)
- Erythrocyte plasma membrane (strong), basolateral membrane of a-intercalated cells of the distal tubules and collecting ducts of the kidney
End of CD Markers > CD233
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