CD Markers
CD24

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 December 2015, last major update June 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD24[title]

Cite this page: CD24. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd24.html. Accessed December 2nd, 2016.
Definition / General
  • A glycosylphosphatidylinositol anchor protein involved in cell adhesion and tumor metastasis
  • Putative cancer stem cell marker
  • References: OMIM #600074
Terminology
  • Also called heat stable antigen homologue (HAS)
Pathophysiology
  • A small glycosylphosphatidylinositol anchor protein with mucin-like adhesion properties
  • Promotes antigen dependent proliferation of B cells and prevents differentiation into plasma cells
Clinical Features
Uses by Pathologists
Micro Images

Images hosted on other servers:

Bladder-normal and ovarian serous adenocarcinoma


Left to right: carcinomas of ampulla (fig e/f), colon, lung, ovary


Urothelium: normal and invasive carcinoma


Bladder carcinoma

Breast: DCIS

Extrahepatic bile duct carcinoma

Salivary gland mucoepidermoid carcinoma (fig B)


Positive Staining - Normal
  • All B cells, granulocytes
  • Also apocrine sweat glands, epithelial cells, fallopian tube, kidney cells, muscle, nucleus pulposus of intervertebral discs (Proc Natl Acad Sci U S A 2006;103:6374) and some neurons
Positive Staining - Disease
Negative Staining
  • Plasma cells, T cells, monocytes, mast cells, red blood cells, platelets; also ovarian epithelium, multiple myeloma and chondrosarcoma