CD Markers
CD24


Topic Completed: 1 June 2014

Revised: 8 August 2019

Revised: 13 December 2018, last major update June 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CD24[title]


Nat Pernick, M.D.
Page views in 2018: 395
Page views in 2019 to date: 339
Cite this page: Pernick N. CD24. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd24.html. Accessed October 14th, 2019.
Definition / general
  • A glycosylphosphatidylinositol anchor protein involved in cell adhesion and tumor metastasis
  • Putative cancer stem cell marker
  • References: OMIM #600074
Terminology
  • Also called heat stable antigen homologue (HAS)
Pathophysiology
  • A small glycosylphosphatidylinositol anchor protein with mucin-like adhesion properties
  • Promotes antigen dependent proliferation of B cells and prevents differentiation into plasma cells
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Bladder: normal and ovarian serous adenocarcinoma

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Bladder carcinoma

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Left to right: colon, lung, ovary


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Urothelium: normal and invasive carcinoma

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Breast: DCIS

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Extrahepatic bile duct carcinoma

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Salivary gland mucoepidermoid carcinoma (fig B)

Positive staining - normal
  • All B cells, granulocytes
  • Also apocrine sweat glands, epithelial cells, fallopian tube, kidney cells, muscle, nucleus pulposus of intervertebral discs (Proc Natl Acad Sci U S A 2006;103:6374) and some neurons
Positive staining - disease
Negative staining
  • Plasma cells, T cells, monocytes, mast cells, red blood cells, platelets; also ovarian epithelium, multiple myeloma and chondrosarcoma
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