CD Markers
CD242

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 Janaury 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: ICAM-4 or LW blood group protein
Definition / General
  • Also called intercellular adhesion molecule 4 (ICAM-4), Landsteiner-Wiener (LW) blood group protein
  • Discovered with antibody raised in guinea pigs injected with the cells of rhesus monkeys, but Rh designation had already been taken
  • Binds to CD11a/CD18, CD11b/CD18 and CD11c/CD18 (Blood 2007;109:802)
  • May be critical in erythroblastic island formation, where erythroid progenitors differentiate (Blood 2006;108:2064)
  • May be ligand for platelet-activated alpha IIb beta 3 integrin (J Biol Chem 2003;278:4892)
  • In sickle cell disease, contributes to red cell-endothelial cell adhesion and vasoocclusion (Transfus Clin Biol 2006;13:44)
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Erythroid cells