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CD Markers

CD27


Reviewers: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 22 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Marker of memory B and T cells

Terminology
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● Also known as tumor necrosis factor receptor superfamily member 7

Physiology
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● Helps differentiate memory-type CD8+ T cells (CD27+) from effector-type CD8+ T cells (effector: important against pathogens, but CD27-) and memory B cells (CD27+) from na´ve B cells (CD27-)
● Binds to CD70
● Marker of T cell activation; may play a role in their survival
● Also regulates B cell activation and immunoglobulin synthesis
● Binds to CD27-binding protein (SIVA), a proapoptotic protein, and may play an important role in apoptosis
● CD70/CD27 axis appears to to regulate immunity versus tolerance (J Leukoc Biol 2010 Aug 10 [Epub ahead of print])

Uses
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● No clinical use by pathologists

Positive stains - normal
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● T cells (including gamma delta T cells, Eur J Immunol 2010 Dec 6 [Epub ahead of print]), memory B cells, NK cells, plasma cells, medullary thymocytes

Positive stains - disease
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● Myelomas (64%, Br J Haematol 2006;132:168)

Negative stains
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● Hairy cell leukemia (Haematologica 2005;90:266)

Additional references
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MIM 186711

End of CD Markers > CD27


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