CD Markers
CD27


Minor changes: 6 July 2020

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PubMed Search: CD27[TI] free full text[SB] pathology

Frido Bruehl, M.D.
Christian M. Schürch, M.D., Ph.D.
Page views in 2019: 26
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Cite this page: Bruehl F, Schürch CM. CD27. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd270.html. Accessed July 6th, 2020.
Definition / general
  • Tumor necrosis factor receptor family member expressed on T and B cells
Essential features
  • CD27 is a costimulatory receptor of the TNF receptor superfamily expressed on lymphocytes
  • CD27 is triggered by its unique ligand CD70, which is expressed on immune cells and often in in cancers
  • Soluble CD27 can be measured in serum and is an indicator of the CD70 - CD27 interaction in vivo
  • CD27 deficiency should be considered in patients with immunodeficiencies and CD27 staining in flow cytometry can help detect immunodeficiencies
Terminology
  • Also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7)
Pathophysiology
Diagrams / tables

Images hosted on other servers:
CD27 signaling in different cancer settings

CD27 signaling in different cancer settings

Clinical features
Interpretation
  • Membranous staining
Uses by pathologists
  • B cell phenotyping for evaluation of immunodeficiency syndromes and immune competence analysis by flow cytometry
  • T cell phenotyping for evaluation of immunodeficiency syndromes and immune competence analysis by flow cytometry
Prognostic factors
  • Solid tumors
    • CD27 positive tumor infiltrating lymphocytes predict inferior survival in renal cell carcinoma (Clin Cancer Res 2015;21:889)
    • CD27 negative tumor infiltrating lymphocytes are associated with an improved survival in high grade serous ovarian carcinoma (Clin Cancer Res 2012;18:3281)
    • CD27 negative tumor infiltrating lymphocytes are associated with an improved survival in hepatocellular carcinoma (Clin Cancer Res 2013;19:5994)
  • Hematolymphoid neoplasms
Microscopic (histologic) description
No information provided
Microscopic (histologic) images

Contributed by Christian Schürch, M.D., Ph.D.
Immunohistochemical double staining (CD27 and CD34)

Immunohistochemical
double staining
(CD27 and CD34)

Virtual slides
No information provided
Positive staining - normal
Positive staining - disease
Negative staining
Flow cytometry images

Contributed by Frido Bruehl, M.D. and Betty Gay, M.D.
Flow cytometry of CVID patient Flow cytometry of CVID patient

Flow cytometry of CVID patient

Molecular / cytogenetics description
No information provided
Molecular / cytogenetics images
No information provided
Sample pathology report
  • Peripheral blood, flow cytometry, quantitative B cell phenotyping analysis:
    • Abnormal (see comment)
    • Comment: A decrease of class switched memory B cells (CD19 positive, CD27 positive, IgM negative, IgD negative) is consistent with common variable immunodeficiency (CVID). Switched memory B cells are quantitatively decreased in relation to marginal zone B cells (CD19 positive, CD27 positive, IgM positive, IgD negative). This result is consistent with but not diagnostic of CVID. Quantitative B cell phenotyping is helpful for the classification and prognosis of CVID and should be considered in the context of clinical and other immunological and laboratory findings. Decreased class switched memory B cells may also be seen in some autoimmune diseases, secondary to certain medications and in patients with other hereditary syndromes.
Board review style question #1
Which statement about CD27 is true?

  1. CD27 expression is consistently absent in B cell lymphoma
  2. CD27 is constitutively expressed in nonlymphoid tissues
  3. CD27 is not expressed on myeloid precursor cells
  4. CD70, the ligand of CD27, is often overexpressed in cancer
  5. There are no current clinical uses of CD27
Board review answer #1
D. CD70 is overexpressed in many cancers and the CD27 / CD70 immune axis is utilized by cancers to escape immune surveillance (Oncoimmunology 2012;1:1604)

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Reference: CD27
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