Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 22 August 2013, last major update February 2002
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD278
- Also called ICOS
- Enhances basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that mediate cell-cell interaction and effective help for antibody secretion by B-cells
- Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens
- Plays a critical role in CD40-mediated class switching of immunoglobin isotypes
- A type I membrane protein
- Defects cause ICOS deficiency (OMIM 607594), a form of common variable immunodeficiency characterized by recurrent bacterial infections of the respiratory and digestive tracts, but without splenomegaly, autoimmune disease, sarcoid-like granulomas, overt T cell immunodeficiency
- Present in: activated T cells, tonsillar T cells, fetal and newborn thymic medulla
End of CD Markers > CD278
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