CD Markers
CD29

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update September 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD29[title]

Cite this page: CD29. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd29.html. Accessed December 6th, 2016.
Definition / General
Terminology
  • Also called glycoprotein IIa (GP IIa), integrin beta-1 (ITGB1), fibronectin receptor beta subunit, VLA (CD49) beta chain
Pathophysiology
  • Common beta subunit of integrins VLA1 to VLA6, which are also composed of alpha subunits alpha 1 to alpha 6 (CD49a-f)
  • Combines with CD49a to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
  • Involved in lymphocyte and endothelial adhesion; important for lymphocyte trafficking and transvascular migration
  • Promotes or inhibits apoptosis, depending on the ligands and apoptotic insults (Cancer Res 2003;63:8302)
  • May help define neural lineage differentiation of stem cells (Stem Cells 2009;27:2928)
Uses by Pathologists
  • Myoepithelial marker, although established markers (SMA, CD10, p63, S100, maspin, calponin, GFAP, smooth muscle myosin) are more commonly used
Micro Images

Images hosted on other servers:

Normal biliary epithelium

Lung cancer

Positive Staining - Normal
  • Fibroblasts, platelets, T cells, monocytes, granulocytes (low), mast cells, endothelial cells and myoepithelium; also other diverse cell types
Positive Staining - Disease
Negative Staining