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CD Markers

CD29


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 19 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Integrin component that mediates adhesion and is involved in homing to sites of inflammation

Terminology
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● Also called integrin beta-1 (ITGB1), fibronectin receptor beta subunit, VLA (CD49) beta chain

Physiology
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● Common beta subunit of integrins VLA1 to VLA6, which are also composed of alpha subunits alpha 1 to alpha 6 (CD49a-f)
● Combines with CD49a to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
● Involved in lymphocyte and endothelial adhesion; important for lymphocyte trafficking and transvascular migration
● Promotes or inhibits apoptosis, depending on the ligands and apoptotic insults (Cancer Res 2003;63:8302)
● May help define neural lineage differentiation of stem cells (Stem Cells 2009;27:2928)

Clinical features
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● Clinical effects of tracrolimus (FK506) may be due to early inhibitory effects of CD29 (Clin Exp Rheumatol 2004;22:197)

Uses
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● Myoepithelial marker, although established markers (SMA, CD10, p63, S100, maspin, calponin, GFAP, smooth muscle myosin) are more commonly used

Micro images
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Normal biliary epithelium

Positive staining - normal
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● Fibroblasts, platelets, T cells, monocytes, granulocytes (low), mast cells, endothelial cells, myoepithelium; also other diverse cell types

Positive staining - disease
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● Bile duct epithelium in alcoholic liver disease (16%, Arch Pathol Lab Med 1999;123:411), breast metaplastic carcinoma (90%, Am J Surg Pathol 2005;29:347), breast sarcoma NOS if CD10+ (43%, Am J Surg Pathol 2006;30:450), myeloma in bone marrow (Br J Haematol 2002;119:70)

Negative staining
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● Red blood cells; intravascular lymphomatosis (Hum Pathol 2000;31:220)

Additional references
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MIM 135630

End of CD Markers > CD29


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