General
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• CD2 epitope present on activated T cells, unmasked by conformational change of CD2 glycoprotein during activation
• No recent articles in literature

Uses by pathologists
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• No significant clinical use by pathologists

Positive staining - normal
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• Activated T cells

Positive staining - disease
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• Blood and synovial fluid T cells in rheumatoid arthritis; peripheral blood T cells in juvenile rheumatoid arthritis, SLE, ankylosing spondylitis and Lyme disease (Scand J Immunol 1991;34:351)

Negative staining
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• Resting T cells

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