CD Markers
CD30

Reviewer: Nat Pernick, M.D. (see Reviewers page)

Revised: 29 December 2015, last major update January 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD30 [title]

Related topics: CD30v
Cite this page: CD30. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd30.html. Accessed December 7th, 2016.
Definition / General
  • Lympocyte activation antigen important in diagnosis of classic Hodgkin's lymphoma, anaplastic large cell lymphoma and embryonal carcinoma
Terminology
  • Also known as Ki-1, Ber-H2
Pathophysiology
  • Member of tumor necrosis factor family of cell surface receptors; also a lymphocyte activation antigen
  • Overexpression causes constitutive expression of nuclear factor-KB, which is considered the molecular basis for aberrant growth and cytokine expression that causes Hodgkin’s lymphoma (Am J Pathol 2003;163:633)
  • Ligand is CD153
  • May also be involved in elimination of autoreactive T cells in thymus
Clinical Features
Interpretation
  • Membranous and Golgi type staining
  • Staining doesn’t work well with prolonged formalin fixation or with B5 fixation
Uses by Pathologists
  • Confirm diagnosis of anaplastic large cell lymphoma, classic Hodgkin's lymphoma, embryonal carcinoma
  • Other lymphoma diagnosis
Micro Images

Images hosted on PathOut server:

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Lymphomatoid papulosis



Anaplastic large cell lymphoma:

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Post liver transplant, FB

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Primary cutaneous, F4

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Brain tumor, HIV patient

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Primary brain tumor, FB

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Sarcomatoid variant, F7

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CD30+ scalp lesion, FB

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Primary bone tumor, F2B

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Strong membrane and golgi staining pattern (site unspecified)

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Small cell variant, anaplastic large cell lymphoma



Classic Hodgkin's lymphoma:

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Membrane staining

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Left to right: pulmonary, F3B; GE junction, FD; EBV+ ileal tumor, FD; colon, F4b

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Membrane and paranuclear staining

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Classic Hodgkin's lymphoma



Other lymphoma:

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Plasmablastic lymphoma, F4

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Atypical cells in follicular lymphoma



Other

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Embryonal carcinoma, F6

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Embryonal carcinoma, intratubular, F4

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Mesothelioma, F5



Positive Staining - Normal
Positive Staining - Disease
Flow Cytometry Images
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Flow cytometry images of anaplastic large cell lymphoma

Additional References