CD Markers
CD30


Topic Completed: 1 January 2011

Minor changes: 16 November 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: CD30 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD30. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd30.html. Accessed December 5th, 2020.
Definition / general
  • CD30: lymphocyte activation antigen important in diagnosis of classic Hodgkin's lymphoma, anaplastic large cell lymphoma and embryonal carcinoma
  • CD30v: variant form of CD30 which retains only the cytoplasmic domain; very little has been published about CD30v
  • Note: all content of this topic is about CD30, unless stated otherwise
Terminology
  • Also known as Ki-1, Ber-H2
Pathophysiology
  • Member of tumor necrosis factor family of cell surface receptors; also a lymphocyte activation antigen
  • Overexpression causes constitutive expression of nuclear factor-KB, which is considered the molecular basis for aberrant growth and cytokine expression that causes Hodgkin’s lymphoma (Am J Pathol 2003;163:633)
  • Ligand is CD153
  • May also be involved in elimination of autoreactive T cells in thymus
Clinical features
Interpretation
  • Membranous and Golgi type staining
  • Staining doesn’t work well with prolonged formalin fixation or with B5 fixation
Uses by pathologists
  • Confirm diagnosis of anaplastic large cell lymphoma, classic Hodgkin's lymphoma, embryonal carcinoma
  • Other lymphoma diagnosis
Microscopic (histologic) images

AFIP images
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Lymphomatoid papulosis



Images hosted on other servers:
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Classic Hodgkin lymphoma: membrane staining

Positive staining - normal
Positive staining - disease
Additional references
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