CD Markers

Topic Completed: 1 January 2011

Minor changes: 14 December 2019

Copyright: 2002-2019,, Inc.

PubMed Search: CD30 [title]

Nat Pernick, M.D.
Page views in 2019: 17,788
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Cite this page: Pernick N. CD30. website. Accessed July 2nd, 2020.
Definition / general
  • CD30: lymphocyte activation antigen important in diagnosis of classic Hodgkin's lymphoma, anaplastic large cell lymphoma and embryonal carcinoma
  • CD30v: variant form of CD30 which retains only the cytoplasmic domain; very little has been published about CD30v
  • Note: all content of this topic is about CD30, unless stated otherwise
  • Also known as Ki-1, Ber-H2
  • Member of tumor necrosis factor family of cell surface receptors; also a lymphocyte activation antigen
  • Overexpression causes constitutive expression of nuclear factor-KB, which is considered the molecular basis for aberrant growth and cytokine expression that causes Hodgkin’s lymphoma (Am J Pathol 2003;163:633)
  • Ligand is CD153
  • May also be involved in elimination of autoreactive T cells in thymus
Clinical features
  • Membranous and Golgi type staining
  • Staining doesn’t work well with prolonged formalin fixation or with B5 fixation
Uses by pathologists
  • Confirm diagnosis of anaplastic large cell lymphoma, classic Hodgkin's lymphoma, embryonal carcinoma
  • Other lymphoma diagnosis
Microscopic (histologic) images

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Lymphomatoid papulosis

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Anaplastic large cell lymphoma:
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Post liver transplant, FB

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Primary cutaneous, F4

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Brain tumor, HIV patient

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Primary brain tumor, FB

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Sarcomatoid variant, F7

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CD30+ scalp lesion, FB

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Primary bone tumor, F2B

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Strong membrane and golgi staining pattern (site unspecified)

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Small cell variant, anaplastic large cell lymphoma

Classic Hodgkin lymphoma:
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Membrane staining

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Left to right: pulmonary, F3B; GE junction, FD; EBV+ ileal tumor, FD; colon, F4b

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Membrane and paranuclear staining

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Classic Hodgkin lymphoma

Other lymphoma:
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Plasmablastic lymphoma, F4

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Atypical cells in follicular lymphoma

Positive staining - normal
Positive staining - disease
Flow cytometry images

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Flow cytometry images of anaplastic large cell lymphoma

Additional references
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