CD Markers

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 12 October 2015, last major update January 2011

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD32 [title]
Definition / General
  • Low affinity receptor to the Fc region of IgG
  • Low affinity receptor on white blood cells (see below) that binds to the Fc region of IgG immune complexes to remove foreign antigens
Clinical Features
Uses by Pathologists
  • Preincubation with CD16/CD32 antibodies is commonly used to prevent nonspecific binding
  • No significant clinical use by pathologists
Positive Staining - Normal
  • CD32a: Monocytes, macrophages; B cells, basophils, eosinophils, granulocytes, NK cells, plasma cells (some), platelets
  • CD32b: Most broadly distributed Fc receptor; monocytes / macrophages; also basophils, B cells eosinophils, Langerhans cells, neutrophils, placenta endothelial cells, platelets; not NK cells
  • CD32c: Monocytes, macrophages, neutrophils, NK cells
Positive Staining - Disease
  • Follicular lymphoma, histiocytic sarcoma
Negative Staining