CD Markers
CD32




Topic Completed: 1 January 2011

Revised: 14 December 2018, last major update January 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD32 [title]
Page views in 2018: 101
Page views in 2019 to date: 28
Cite this page: Pernick N. CD32. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd32.html. Accessed March 20th, 2019.
Definition / general
  • Low affinity receptor to the Fc region of IgG
Terminology
Pathophysiology
  • Low affinity receptor on white blood cells (see below) that binds to the Fc region of IgG immune complexes to remove foreign antigens
Clinical features
Uses by pathologists
  • Preincubation with CD16/CD32 antibodies is commonly used to prevent nonspecific binding
  • No significant clinical use by pathologists
Positive staining - normal
  • CD32a: Monocytes, macrophages; B cells, basophils, eosinophils, granulocytes, NK cells, plasma cells (some), platelets
  • CD32b: Most broadly distributed Fc receptor; monocytes / macrophages; also basophils, B cells eosinophils, Langerhans cells, neutrophils, placenta endothelial cells, platelets; not NK cells
  • CD32c: Monocytes, macrophages, neutrophils, NK cells
Positive staining - disease
  • Follicular lymphoma, histiocytic sarcoma
Negative staining
Back to top