Reviewers: Nat Pernick, M.D. (see Reviewers page)
Revised: 22 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Low affinity receptor to the Fc region of IgG
● Also called Fc gamma RII; subtyped as Fc gamma RIIa (MIM 146790), RIIb (MIM 604590) and RIIc (MIM 612169)
● Low affinity receptor on white blood cells (see below) that binds to the Fc region of IgG immune complexes to remove foreign antigens
● Polymorphisms affects incidence or severity of some diseases, including antiphospholipid syndrome (Arthritis Rheum 2003;48:1930), IgA nephropathy (Nephrol Dial Transplant 2005;20:2439), malaria (Am J Trop Med Hyg 2003;69:565), myasthenia gravis (J Neuroimmunol 2003;144:143), onchocerciasis (Am J Trop Med Hyg 2007;77:1074), peripheral atherosclerosis (Thromb Haemost 2004;92:1273), rheumatic fever (Clin Biochem 2004;37:925) and systemic lupus erythematosus (Arthritis Rheum 2002;46:1563)
● In dendritic cells, CD32a is considered an activating isoform and CD32b an inhibitory isoform; the balance between these receptors establishes a threshold of activation and enables immune complexes to mediate opposing effects on dendritic cell maturation and function (J Clin Invest 2005;115:2914)
● Preincubation with CD16/CD32 antibodies is commonly used to prevent nonspecific binding
● No significant clinical use by pathologists
Positive staining - normal
● CD32a: Monocytes, macrophages; B cells, basophils, eosinophils, granulocytes, NK cells, plasma cells (some), platelets
● CD32b: Most broadly distributed Fc receptor; monocytes / macrophages; also basophils, B cells eosinophils, Langerhans cells, neutrophils, placenta endothelial cells, platelets; not NK cells
● CD32c: Monocytes, macrophages, neutrophils, NK cells
Positive staining - disease
● Follicular lymphoma, histiocytic sarcoma
● T cells (usually, Immunology 1997;90:109)
End of CD Markers > CD32
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