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CD Markers
CD34

Reviewer: Lauren Stuart, M.D. (see Reviewers page)
Revised: 4 July 2013, last major update May 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Physiology
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Clinical features
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Interpretation
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Uses by pathologists
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Micro images
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Normal:

Blasts and megakaryocytes

Various images to assess quality control

Liver


Fibroblastic cells (CD34+ in normal stomach, CD34- in intestinal gastric carcinoma)


CD34+ stromal cells (normal stomach & colon, gastric adenocarcinoma)


CD34+ vascular endothelial cells (normal and gastric adenocarcinoma)


Gastrointestinal stromal tumor / GIST:

GIST vs. SFT

Extraintestinal GIST

Stomach GISTs


Solitary fibrous tumor:

Bladder

Kidney

Pleura (malignant tumor)

Thigh


Vascular tumors:

Angiosarcomas: liver

Oral cavity (fig 7C)

Ovary

Skin-scalp


Epithelioid angiosarcoma of bone (left); lung (right)


Hemangioendothelioma of heart (left); infantile liver (right)


Epithelioid hemangioendothelioma of bone (left, fig 2B); CNS (right, fig F)

Of pleura (left, fig E); liver (right)


Glomangioma of liver


Hemangiomas, capillary type: endometrium (left, fig 2C); testis (right, fig 1B)


Hemangiomas, cavernous type: lung (left, fig 1C); spermatic cord (right, fig B)

Juvenile (FNA)


Hemangiopericytoma of CNS is CD34+ (left) and CD31 negative (right)


Kaposi's sarcoma


Various liver vascular tumors


Other:

Aggressive angiomyxoma: penis/scrotum (left); spermatic cord (right)


preB-ALL: kidney (left); skin tumor is CD34+ (right)


Angiomyofibroblastoma of male
inguinal region (fig 2C)

Breast carcinoma: vessels
CD34+ but tumor cells negative


Chronic myelogenous leukemia
in blast crisis (fig 1B)

Endosalpingiosis of omentum


Epithelioid sarcoma is CD34+

Inflammatory fibroid polyp of stomach


Leukemia vasculitis in leukemia cutis due to atypical CML:
tumor cells are CD34 negative, but vessels are CD34+

Littoral cell angioma of
spleen is CD34 negative


Hepatocellular carcinoma: tumor cells are CD34 negative, but intravascular tumor clusters are lined by CD34+ endothelial cells


Mammary type myofibroblastoma of soft tissue is CD34+

Myeloid sarcoma of bone


Myofibroma is CD34 negative

Neurothekeoma is CD34 negative


Perineurioma, extraneural


Pseudoangiomatous hyperplasia (PASH) of breast: stroma is CD34+


Sinonasal hemangiopericytoma is CD34 negative

Solitary sclerotic fibroma of finger


Spindle cell lipoma has CD34+ stroma: breast (left); salivary glands (middle, fig D); neck tumor is pseudoangiomatous variant (right)


Storiform collagenoma

Superficial acral fibromyxoma of soft tissue (fig 2)


Serous borderline tumor

CD34 distinguishes displaced epithelium
from vascular invasion (fig F)


CD34 positive fibroblastic cells

Fibrotic stroma and epithelial component (fig 7)

Neuroma (fig B)


Vascular leiomyoma (fig A)

Multinodular architecture


CD34 positive tumors

CD34 negative tumors


Positive staining - normal
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Positive staining - disease
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Negative staining
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End of CD Markers > CD34


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