CD Markers - CD35

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CD Markers

CD35

Reviewers: Nat Pernick, M.D. (see Reviewers page)
Revised: 25 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Dendritic cell marker; mediates cellular binding of particles and immune complexes that have activated complement

Terminology
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● Also called erythrocyte complement receptor 1 (CR1), C3b and C4b receptor

Physiology
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● Binds immune complexes coated with C3b or C4b and mediates their transport to and removal by the fixed phagocyte systems of the spleen and liver
● Cofactor for specific proteolytic cleavage of C3b and C4b by plasma serine protease factor I, which limits complement activation and produces ligands for other complement receptors
● The Knops, McCoy, Swain-Langley, and York blood group antigens are located on CD35 (more information)
● Follicular dendritic cells form a reticular network in the lymphoid follicle necessary to retain and present native antigens (in the form of antigen-antibody immune complexes) to B cells during the secondary immune response
● CD21, CD23 and CD35 are dendritic cell markers

Clinical features
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● Reduced expression in erthrocytes in gallbladder carcinoma (World J Gastroenterol 2004;10:3480), preeclampsia (Am J Reprod Immunol 2005;54:352), severe acute respiratory syndrome (Clin Exp Immunol 2005;139:112), mesangiocapillary glomerulonephritis, systemic lupus erythematosis (Arthritis Rheum 2004;50:3596)
● Acts as a malaria resistance gene, and deficiencies of CR1 are protective against Plasmodium falciparum (Proc Natl Acad Sci USA 2004;101:272)
● A specific genotype is associated with sarcoidosis in females (Am J Respir Cell Mol Biol 2002;27:17)

Uses
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● Diagnose follicular dendritic cell sarcoma (Am J Surg Pathol 1996;20:944)
● Highlight or confirm lack of dendritic cell germinal center meshwork (example: splenic B cell lymphoma, Am J Surg Pathol 2003;27:903)

Micro images
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Follicular dendritic cell tumors
Left - duodenal mass; Middle - liver mass (figure 2c); Right - intraabdominal mass (figure 2d)

Figure B

Prominent network of CD21+ follicular dendritic cells in abnormal germinal center of Castleman's disease

Positive staining - normal
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● Follicular dendritic cells, erythrocytes; basophils, eosinophils, granulocytes, monocytes, macrophages (some), B cells, T cells (10%), NK cell subset, some astrocytes

Positive staining - disease
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● Follicular dendritic cell sarcoma (Am J Surg Pathol 1998;22:1048, Mod Pathol 2002;15:50), Hodgkin’s lymphoma (Reed-Sternberg cells in 5%, Am J Surg Pathol 1999;23:363), inflammatory GI fibroid polyps (focal in stromal cells, Am J Surg Pathol 2004;28:107), splenic marginal zone lymphoma (some cases, Am J Surg Pathol 2007;31:438)
● Occasionally other B cell lymphomas (J Appl Oral Sci 2009;17:248)

Negative staining
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● Langerhans cells (normal and tumors)
● Fibroblastic reticulum cell tumor, gastrointestinal stromal tumor, histiocytic sarcoma (Am J Surg Pathol 1994;28:1133), inflammatory myofibroblastic tumor (Am J Surg Pathol 1998;22:412), interdigitating dendritic cell tumor (Am J Surg Pathol 1999;23:1141)

Additional references
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● MIM 120620

End of CD Markers > CD35

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