CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD35 [title]
Cite this page: CD35. website. Accessed October 20th, 2016.
Definition / General
  • Dendritic cell marker
  • Mediates cellular binding of particles and immune complexes that have activated complement
  • Also called erythrocyte complement receptor 1 (CR1), C3b and C4b receptor
  • Binds immune complexes coated with C3b or C4b and mediates their transport to and removal by the fixed phagocyte systems of the spleen and liver
  • Cofactor for specific proteolytic cleavage of C3b and C4b by plasma serine protease factor I, which limits complement activation and produces ligands for other complement receptors
  • The Knops, McCoy, Swain-Langley, and York blood group antigens are located on CD35 (Blood Group Antigen Gene Mutation Database)
  • Follicular dendritic cells form a reticular network in the lymphoid follicle necessary to retain and present native antigens (in the form of antigen-antibody immune complexes) to B cells during the secondary immune response
  • CD21, CD23 and CD35 are dendritic cell markers
Clinical Features
Uses by Pathologists
Micro Images

Images hosted on PathOut server:

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Follicular dendritic cell tumor

Images hosted on Other servers:

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Liver mass

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Intraabdominal mass

Positive Staining - Normal
  • Follicular dendritic cells, erythrocytes
  • Basophils, eosinophils, granulocytes, monocytes, macrophages (some), B cells, T cells (10%), NK cell subset, some astrocytes
Positive Staining - Disease
Negative Staining
Additional References