Pathology Outlines

CD Markers
CD35

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 September 2018, last major update January 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD35 [title]

Table of Contents

Cite this page: Pernick, N. CD35. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd35.html. Accessed October 19th, 2018.

Definition / general

Dendritic cell marker
Mediates cellular binding of particles and immune complexes that have activated complement

Terminology

Also called erythrocyte complement receptor 1 (CR1), C3b and C4b receptor

Pathophysiology

Binds immune complexes coated with C3b or C4b and mediates their transport to and removal by the fixed phagocyte systems of the spleen and liver
Cofactor for specific proteolytic cleavage of C3b and C4b by plasma serine protease factor I, which limits complement activation and produces ligands for other complement receptors
The Knops, McCoy, Swain-Langley, and York blood group antigens are located on CD35 (Blood Group Antigen Gene Mutation Database)
Follicular dendritic cells form a reticular network in the lymphoid follicle necessary to retain and present native antigens (in the form of antigen-antibody immune complexes) to B cells during the secondary immune response
CD21, CD23 and CD35 are dendritic cell markers

Clinical features

Reduced expression in erthrocytes in gallbladder carcinoma (World J Gastroenterol 2004;10:3480), preeclampsia (Am J Reprod Immunol 2005;54:352), severe acute respiratory syndrome (Clin Exp Immunol 2005;139:112), mesangiocapillary glomerulonephritis, systemic lupus erythematosis (Arthritis Rheum 2004;50:3596)
Acts as a malaria resistance gene, and deficiencies of CR1 are protective against Plasmodium falciparum (Proc Natl Acad Sci USA 2004;101:272)
A specific genotype is associated with sarcoidosis in females (Am J Respir Cell Mol Biol 2002;27:17)

Uses by pathologists

Diagnose follicular dendritic cell sarcoma (Am J Surg Pathol 1996;20:944)
Highlight or confirm lack of dendritic cell germinal center meshwork
- For example: splenic B cell lymphoma (Am J Surg Pathol 2003;27:903)

Microscopic (histologic) images

Images hosted on PathOut server:

Follicular dendritic cell tumor

Images hosted on other servers:

Liver mass

Intraabdominal mass

Positive staining - normal

Follicular dendritic cells, erythrocytes
Basophils, eosinophils, granulocytes, monocytes, macrophages (some), B cells, T cells (10%), NK cell subset, some astrocytes

Positive staining - disease

Follicular dendritic cell sarcoma (Am J Surg Pathol 1998;22:1048, Mod Pathol 2002;15:50), Hodgkin lymphoma (Reed-Sternberg cells in 5%, Am J Surg Pathol 1999;23:363), inflammatory GI fibroid polyps (focal in stromal cells, Am J Surg Pathol 2004;28:107), splenic marginal zone lymphoma (some cases, Am J Surg Pathol 2007;31:438)
Occasionally other B cell lymphomas (J Appl Oral Sci 2009;17:248)

Negative staining

Langerhans cells (normal and tumors)
Fibroblastic reticulum cell tumor, gastrointestinal stromal tumor, histiocytic sarcoma (Am J Surg Pathol 1994;28:1133), inflammatory myofibroblastic tumor (Am J Surg Pathol 1998;22:412), interdigitating dendritic cell tumor (Am J Surg Pathol 1999;23:1141)

Additional references

OMIM - 120620