CD Markers
CD352

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 January 2016, last major update January 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: SLAMF6
General
  • First described as CD352 at HLDA9 in 2011 (Immunol Lett 2011;134:104)
  • Also known as Signaling lymphocytic activation molecule F6 (SLAMF6), Ly108 and NTBA
Pathophysiology
  • Member of SLAM (CD150) family of receptors, which are leukocyte cell-surface glycoproteins involved in leukocyte activation; these molecules and their adaptor protein SAP contribute to germinal center formation, generation of plasma cells and memory B cells (Immunol Lett 2011;134:129)
  • Costimulatory molecule with CD28 implicated in formation of Th17 lymphocytes and IL17A expression (J Biol Chem 2012;287:38168)
Diagrams / Tables

T cell receptor signalling

Clinical Features
Uses by Pathologists
  • None at this time
Positive Staining - Normal