CD Markers
CD352


Topic Completed: 1 January 2014

Revised: 20 December 2018, last major update January 2014

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PubMed Search: SLAMF6

Nat Pernick, M.D.
Page views in 2018: 30
Page views in 2019 to date: 12
Cite this page: Pernick N. CD352. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd352.html. Accessed July 18th, 2019.
Definition / general
  • First described as CD352 at HLDA9 in 2011 (Immunol Lett 2011;134:104)
  • Also known as Signaling lymphocytic activation molecule F6 (SLAMF6), Ly108 and NTBA
Pathophysiology
  • Member of SLAM (CD150) family of receptors, which are leukocyte cell-surface glycoproteins involved in leukocyte activation; these molecules and their adaptor protein SAP contribute to germinal center formation, generation of plasma cells and memory B cells (Immunol Lett 2011;134:129)
  • Costimulatory molecule with CD28 implicated in formation of Th17 lymphocytes and IL17A expression (J Biol Chem 2012;287:38168)
Diagrams / tables

T cell receptor signalling

Clinical features
Uses by pathologists
  • None at this time
Positive staining - normal
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