CD Markers

Topic Completed: 1 January 2014

Revised: 20 December 2018, last major update January 2014

Copyright: (c) 2003-2016,, Inc.

PubMed Search: SLAMF8

Nat Pernick, M.D.
Page views in 2018: 14
Page views in 2019 to date: 17
Cite this page: Pernick N. CD353. website. Accessed December 12th, 2019.
Definition / general
  • Also known as SLAMF8
  • First described at HLAD9 in 2011 (Immunol Lett 2011;134:104)
  • Member of CD2 family of cell surface proteins involved in lymphocyte activation (Wikipedia)
  • Cell surface receptor expressed upon activation of macrophages by IFN-γ or bacteria
  • Negatively regulates inflammatory responses via very high NADPH oxidase (Nox2) enzyme activity (J Immunol 2012;188:5829)
Clinical features
Uses by pathologists
  • None at this time
Positive staining - normal
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