CD Markers
CD354 (TREM1)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update April 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: TREM1

Definition / General
  • Triggering REceptor on Myeloid cells; member of Ig superfamily
  • sTREM1: soluble levels of TREM1
  • Part of family of immune sensors which signal innate immune system and amplifies immune responses that promote pro-inflammatory cytokine production; neutrophils are major source of TREM1
  • TREM1 is an activating receptor and requires association with transmembrane adapter molecule DAP12 (DNAX-associated protein 12) for cell signaling (PLoS One 2013;8:e82498, J Leukoc Biol 2013;93:209)
Pathophysiology / Etiology
  • TREM1 and MMPs orchestrate an "adaptive" form of innate immunity by modulating the monocyte response to endotoxin (J Leukoc Biol 2012;91:933)
  • Dendritic cells: TREM1 induction by hypoxic microenvironment activates immature dendritic cells and regulates Th1 cell trafficking (Eur J Immunol 2013;43:949)
Clinical Features
Uses by Pathologists
Micro Images

Images hosted on other servers:

Hydronephrosis

Acute cutaneous folliculitis (a); impetigo (c); B. henselae (e); fumigatus (g)

Positive Staining - Normal
  • Myeloid cells