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CD Markers

CD37


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151)
● Regulates T cell proliferation (J Immunol 2004;172:2953)

Clinical features
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● Inhibits IgA responses and regulates the anti-fungal immune response (PLoS Pathog 2009;5:e1000338)

Uses
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● No significant clinical use by pathologists

Positive staining - normal
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● B cells, T cells (low), neutrophils (low), monocytes (low), macrophages, dendritic cells

Positive staining - disease
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● Most B cell lymphomas (Leukemia 1994;8:1864), some T cell lymphomas

Negative staining
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● NK cells, platelets, erythrocytes, plasma cells
● Plasma cell neoplasms, preB-ALL (or low)

Additional references
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MIM 151523

End of CD Markers > CD37


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