CD Markers
CD39



Topic Completed: 01 January 2011

Revised: 14 December 2018, last major update January 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD39 [title]
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Cite this page: Pernick N. CD39. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd39.html. Accessed January 19th, 2019.
Definition / general
  • Endothelial ATPase that blocks platelet activation
Terminology
  • Also called ectonucleoside triphosphate diphosphohydrolase (NTPDase-1)
Pathophysiology
  • Plasma membrane-bound enzyme that hydrolyzes extracellular ATP and ADP to AMP (Platelets 2005;16:159), and acts as important inhibitor of platelet activation by blocking platelet aggregation responses to ADP
  • Also degrades the extracellular ATP released during tissue injury, which otherwise would trigger inflammation
  • Highly expressed on regulatory Foxp3(+) CD4 T cells
  • May have a therapeutic anti-thrombotic effect (Semin Thromb Hemost 2005;31:234)
  • Its biochemical activity is lost at sites of acute vascular injury, such as in ischemia reperfusion and immune graft rejection (Blood Cells Mol Dis 2006;36:217)
  • Also regulates vascular and immune cell adhesion and signaling events pivotal in inflammation (Biochem J 2006;396:23)
Clinical features
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

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Donor liver

Positive staining - normal
Additional references