CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD39 [title]
Cite this page: CD39. website. Accessed October 21st, 2016.
Definition / General
  • Endothelial ATPase that blocks platelet activation
  • Also called ectonucleoside triphosphate diphosphohydrolase (NTPDase-1)
  • Plasma membrane-bound enzyme that hydrolyzes extracellular ATP and ADP to AMP (Platelets 2005;16:159), and acts as important inhibitor of platelet activation by blocking platelet aggregation responses to ADP
  • Also degrades the extracellular ATP released during tissue injury, which otherwise would trigger inflammation
  • Highly expressed on regulatory Foxp3(+) CD4 T cells
  • May have a therapeutic anti-thrombotic effect (Semin Thromb Hemost 2005;31:234)
  • Its biochemical activity is lost at sites of acute vascular injury, such as in ischemia reperfusion and immune graft rejection (Blood Cells Mol Dis 2006;36:217)
  • Also regulates vascular and immune cell adhesion and signaling events pivotal in inflammation (Biochem J 2006;396:23)
Diagrams / Tables

Nature images:

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CD39 and platelet activation

Clinical Features
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

Image hosted on Other server:

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Donor liver

Positive Staining - Normal
Additional References