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CD Markers

CD41


Reviewers: Nat Pernick, M.D. (see Reviewers page)
Revised: 22 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Platelet glycoprotein IIb, important for platelet aggregation

Terminology
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● Also called platelet glycoprotein IIb, GPIIb, platelet fibrinogen receptor alpha subunit

Physiology
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● Gene encodes integrin alpha chain 2b, which undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a fibronectin receptor expressed in platelets, which is crucial for platelet aggregation through binding of soluble fibrinogen
● GP IIb/IIIa is also a receptor for fibrinogen, plasminogen, prothrombin, thrombosponin, vitronectin and von Willebrand factor
● Recognizes the sequence R-G-D in a wide array of ligands
● Downregulated by factor XIII and calpain (J Biol Chem 2004;279:30697)

Clinical features
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● Mutations cause Glanzmann thrombasthenia (MIM 273800), with a tendency to bleed for prolonged periods following injury

Uses
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● Identify platelets or megakaryocytes (marker is specific)
● Isolate platelets (Cytometry A 2005;65:84)
● Confirm diagnosis of AML-M7
● Diagnose Glanzmann thrombasthenia

Micro images
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CML in blast transformation - megakaryocytes and platelets are CD41+

Positive staining - normal
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● Platelets, megakaryocytes, hematopoietic progenitor cells (erythroid, myeloid, megakaryocytes, Br J Haematol 1999;105:1044, Development 2002;129:2003), mast cells (Exp Hematol 2005;33:403)

Positive staining - disease
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● AML M7, blasts in transient myeloproliferative disorder (Am J Clin Pathol 2001;116:204)

Negative staining
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● AML M0 to M6

Additional references
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MIM 607759, J Clin Invest 2005;115:3363, Arterioscler Thromb Vasc Biol 2003;23:945

End of CD Markers > CD41


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