CD Markers
CD41

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD41
Definition / General
  • Platelet glycoprotein IIb, important for platelet aggregation
Terminology
  • Also called platelet glycoprotein IIb, GPIIb, platelet fibrinogen receptor alpha subunit
Pathophysiology
  • Gene encodes integrin alpha chain 2b, which undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a fibronectin receptor expressed in platelets, which is crucial for platelet aggregation through binding of soluble fibrinogen
  • GP IIb/IIIa is also a receptor for fibrinogen, plasminogen, prothrombin, thrombosponin, vitronectin and von Willebrand factor
  • Recognizes the sequence R-G-D in a wide array of ligands
  • Downregulated by factor XIII and calpain (J Biol Chem 2004;279:30697)
Clinical Features
  • Mutations cause Glanzmann thrombasthenia (MIM 273800), with a tendency to bleed for prolonged periods following injury
Uses by Pathologists
  • Identify platelets or megakaryocytes (marker is specific)
  • Isolate platelets (Cytometry A 2005;65:84)
  • Confirm diagnosis of AML-M7
  • Diagnose Glanzmann thrombasthenia
Positive Staining - Normal
Positive Staining - Disease
Negative Staining
  • AML M0 to M6