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CD Markers

CD42a


Reviewers: Charanjeet Singh, M.D., University of Minnesota (see Reviewers page)
Revised: 23 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● CD42a-d complex is receptor for von Willebrand factor and thrombin

Terminology
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● Also called platelet glycoprotein GPIX, GP9

Physiology
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● CD42a-d complex is receptor for von Willebrand factor and thrombin
● This complex mediates adhesion of platelets to subendothelial matrices that are exposed in damaged endothelium and amplifies platelet response to thrombin
● GP-IX (CD42a) is a small membrane protein glycoprotein that forms a noncovalent complex with GP-Ib (CD42b)
● Actual binding site of vWF and thrombin is on CD42b

Drawings
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CD42a-d complex

Clinical features
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● Absence of CD42 complex (mutations in CD42a-c) causes Bernard-Soulier syndrome (giant platelet syndrome, OMIM 231200), a bleeding disorder with thrombocytopenia, prolonged bleeding time and giant platelets

Uses for pathologists
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● No significant clinical use by pathologists

Positive stains - normal
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● Platelets and megakaryocytes

Negative stains
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● Red blood cells, T cells

Additional references
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MIM 173515

End of CD Markers > CD42a


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