CD Markers
CD42c

Author: Nat Pernick M.D. (see Authors page)

Revised: 7 January 2016, last major update December 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD42c

Related: CD42a, CD42b, CD42d

Definition / General
  • CD42a-d complex is receptor for von Willebrand factor and thrombin
  • Also called platelet GPIb beta, glycoprotein Ib-beta
  • Mutations are associated with Bernard-Soulier syndrome (giant platelet syndrome, OMIM #231200, Int J Hematol 2002;76:319), a bleeding disorder with thrombocytopenia, prolonged bleeding time and giant platelets
  • Reduced levels are associated with bleeding disorders in AML patients (Saudi Med J 2005;26:1095)
Diagrams / Tables
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CD42a-d complex

Pathophysiology
  • CD42a-d complex is receptor for von Willebrand factor and thrombin
  • GPIb alpha (CD42b) and GPIb beta (CD42c) form main part of VWF receptor
  • CD42c also amplifies the platelet response to thrombin during platelet activation where thrombin is involved
  • Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein
Case Reports
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal