CD Markers
CD42c


Topic Completed: 1 December 2010

Minor changes: 4 December 2019

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PubMed Search: CD42c

Nat Pernick, M.D.
Page views in 2019: 49
Page views in 2020 to date: 27
Cite this page: Pernick N. CD42c. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd42c.html. Accessed August 13th, 2020.
Definition / general
  • CD42a-d complex is receptor for von Willebrand factor and thrombin
  • Also called platelet GPIb beta, glycoprotein Ib-beta
  • Mutations are associated with Bernard-Soulier syndrome (giant platelet syndrome, OMIM #231200, Int J Hematol 2002;76:319), a bleeding disorder with thrombocytopenia, prolonged bleeding time and giant platelets
  • Reduced levels are associated with bleeding disorders in AML patients (Saudi Med J 2005;26:1095)
Diagrams / tables
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CD42a-d complex

Pathophysiology
  • CD42a-d complex is receptor for von Willebrand factor and thrombin
  • GPIb alpha (CD42b) and GPIb beta (CD42c) form main part of VWF receptor
  • CD42c also amplifies the platelet response to thrombin during platelet activation where thrombin is involved
  • Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein
Case reports
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
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