CD Markers - CD42d

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CD Markers

CD42d

Reviewers: Charanjeet Singh, M.D., University of Minnesota (see Reviewers page)
Revised: 23 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● CD42a-d complex is receptor for von Willebrand factor and thrombin

Terminology
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● Also called platelet GP V, GP5

Physiology
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● Part of CD42a-d complex
● May activate residual platelets in thrombocytopenia regardless of its origin as immune thrombocytopenic purpura or thrombocytopenia of aplastic pancytopenia (J Natl Med Assoc 2008;100:86)
● Also involved in binding of thrombin (Blood 1997;89:4355)

Drawings
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CD42a-d complex

Thrombin binding site

Clinical features
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● Aspirin induces shedding of CD42d and CD42b from platelets (J Biol Chem 2005;280:39716)
● CD42d is the predominant target antigen in gold-induced autoimmune thrombocytopenia (Blood 2002;100:344)
● Deficiency does NOT appear to cause Bernard-Soulier syndrome (Blood 1999;94:4112)

Uses for pathologists
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● No significant clinical use by pathologists

Positive stains - normal
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● Platelets and megakaryocytes

Additional references
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● MIM 173511

End of CD Markers > CD42d

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