Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

CD Markers

CD42d


Reviewers: Charanjeet Singh, M.D., University of Minnesota (see Reviewers page)
Revised: 23 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
=========================================================================

● CD42a-d complex is receptor for von Willebrand factor and thrombin

Terminology
=========================================================================

● Also called platelet GP V, GP5

Physiology
=========================================================================

● Part of CD42a-d complex
● May activate residual platelets in thrombocytopenia regardless of its origin as immune thrombocytopenic purpura or thrombocytopenia of aplastic pancytopenia (J Natl Med Assoc 2008;100:86)
● Also involved in binding of thrombin (Blood 1997;89:4355)

Drawings
=========================================================================


CD42a-d complex

Thrombin binding site

Clinical features
=========================================================================

● Aspirin induces shedding of CD42d and CD42b from platelets (J Biol Chem 2005;280:39716)
● CD42d is the predominant target antigen in gold-induced autoimmune thrombocytopenia (Blood 2002;100:344)
● Deficiency does NOT appear to cause Bernard-Soulier syndrome (Blood 1999;94:4112)

Uses for pathologists
=========================================================================

● No significant clinical use by pathologists

Positive stains - normal
=========================================================================

● Platelets and megakaryocytes

Additional references
=========================================================================

MIM 173511

End of CD Markers > CD42d


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).