CD Markers
CD42d

Author: Nat Pernick M.D. (see Authors page)

Revised: 7 January 2016, last major update December 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD42d

Related: CD42a, CD42b, CD42c

Cite this page: CD42d. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd42d.html. Accessed December 2nd, 2016.
Definition / General
  • CD42a-d complex is receptor for von Willebrand factor and thrombin
  • Also called platelet GP V, GP5
  • Aspirin induces shedding of CD42d and CD42b from platelets (J Biol Chem 2005;280:39716)
  • CD42d is the predominant target antigen in gold-induced autoimmune thrombocytopenia (Blood 2002;100:344)
  • Deficiency does NOT appear to cause Bernard-Soulier syndrome (Blood 1999;94:4112)
Diagrams / Tables
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CD42a-d complex

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Thrombin binding site

Pathophysiology
  • Part of CD42a-d complex
  • May activate residual platelets in thrombocytopenia regardless of its origin as immune thrombocytopenic purpura or thrombocytopenia of aplastic pancytopenia (J Natl Med Assoc 2008;100:86)
  • Also involved in binding of thrombin (Blood 1997;89:4355)
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Platelets and megakaryocytes
Additional References