CD Markers
CD43


Topic Completed: 1 January 2011

Revised: 12 August 2019

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CD43

Nat Pernick, M.D.
Page views in 2018: 10,246
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Cite this page: Pernick N. CD43. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd43.html. Accessed October 13th, 2019.
Definition / general
  • Pan T cell marker important in T cell and neutrophil adhesion to endothelium
Terminology
  • Also called leukosialin, sialophorin
Pathophysiology
Clinical features
  • Has defective expression in T cells of males with Wiskott-Aldrich syndrome (MIM 301000)
Uses by pathologists
  • Pan T cell marker
  • Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211)
  • Classify subtypes of T cell lymphomas and low grade B cell lymphomas
  • Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)
Microscopic (histologic) images

Images hosted on PathOut server:

Left: leukemia cutis; right: MALT lymphoma of stomach



Images hosted on other servers:
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Mantle cell lymphoma

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Anaplastic large cell lymphoma

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Anaplastic lymphoma: left - breast (fig C); middle - post transplant tumor of stomach (fig D); right - AIDS associated


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Left: CD4+ / CD56+ hematodermic neoplasm / blastic NK lymphoma; right: myeloid sarcoma of breast
(fig 6)

Positive staining - normal
Positive staining - disease
Negative staining
  • Colonic epithelium, follicular lymphoma, Hodgkin’s lymphoma, lymphoepithelioma-like thymic carcinoma, primary effusion lymphoma, splenic marginal zone lymphoma
Additional references
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