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CD Markers

CD43


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 29 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Pan T cell marker important in T cell and neutrophil adhesion to endothelium

Terminology
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● Also called leukosialin, sialophorin

Physiology
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● Serves as a ligand for E-selectin on T cells and may regulate T cell trafficking (Blood 2006;107:1421, J Immunol 2005;175:8042)
● Has both antiadhesive and proadhesive roles in neutrophil rolling (J Immunol 2008;181:3628)

Clinical features
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● Has defective expression in T cells of males with Wiskott-Aldrich syndrome (MIM 301000)

Uses
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● Pan T cell marker
● Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211)
● Classify subtypes of T cell lymphomas and low grade B cell lymphomas
● Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)

Micro images
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Left: leukemia cutis; middle: MALT lymphoma of stomach; right: mantle cell lymphoma

       

Left and middle: Anaplastic large cell lymphoma; right: diffuse large B cell lymphoma (infiltrating T cells are CD43+)

       

Anaplastic lymphoma: left - breast (fig c); middle - post transplant tumor of stomach (fig D); right - AIDS associated

   

Left: CD4+/CD56+ hematodermic neoplasm / blastic NK lymphoma; right: myeloid sarcoma of breast (fig6)

Positive staining - normal
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● Most T cells, activated B cells, B cells in terminal ileum (Appl Immunohistochem Mol Morphol 2005;13:138), plasma cells (Scand J Immunol 1991;33:211)
● Basophils, erythrocytes, granulocytes, hematogones (Br J Haematol 2005;128:820), macrophages (some), megakaryocytes, monocytes, NK cells, platelets (weak)
● Brain, Langerhans cells, thymocytes

Positive staining - disease
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T/NK cell lymphomas - anaplastic large cell (variable), CD4+/CD56+ hematodermic neoplasm / blastic NK (Am J Surg Pathol 2005;29:1274), hepatosplenic gamma-delta T cell, NK/T cell-nasal type (96%, Hum Pathol 2004;35:86), peripheral T cell, subcutaneous panniculitis-like
B cell lymphomas - ALL (most), Burkitt’s (almost all), Burkitt’s-like (almost all, Am J Surg Pathol 2005;29:1652), lymphoblastic (variable), mantle cell (100%, Am J Clin Path 2003;119:218), marginal zone (variable, most common in salivary gland, stomach, and upper aerodigestive tract, Arch Pathol Lab Med 2007;131:1673), nodal marginal zone (variable, Am J Surg Pathol 2003;27:762), plasmablastic, SLL/CLL (Am J Clin Path 1999;112:319)
Other: AML (including leukemia cutis, Am J Clin Pathol 2009;132:101), granulocytic sarcoma, hemangioma, Langerhans cell histiocytosis, mast cell disease (Am J Surg Pathol 2000;24:703), plasmacytoma; early colonic adenoma (Oncol Rep 2004;11:327)

Negative staining
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● Colonic epithelium, follicular lymphoma, Hodgkin’s lymphoma, lymphoepithelioma-like thymic carcinoma, primary effusion lymphoma, splenic marginal zone lymphoma

Additional references
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MIM 182160

End of CD Markers > CD43


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