CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CD43
Cite this page: CD43. website. Accessed June 25th, 2018.
Definition / general
  • Pan T cell marker important in T cell and neutrophil adhesion to endothelium
  • Also called leukosialin, sialophorin
Clinical features
  • Has defective expression in T cells of males with Wiskott-Aldrich syndrome (MIM 301000)
Uses by pathologists
  • Pan T cell marker
  • Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211)
  • Classify subtypes of T cell lymphomas and low grade B cell lymphomas
  • Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)
Microscopic (histologic) images

Images hosted on Pathout server:

Left: leukemia cutis; Right: MALT lymphoma of stomach

Images hosted on other servers:

Right: mantle cell lymphoma

Anaplastic large cell lymphoma

Anaplastic lymphoma: Left - breast (fig C); Middle - post transplant tumor of stomach (fig D); Right - AIDS associated

Left: CD4+/CD56+ hematodermic neoplasm / blastic NK lymphoma; Right: myeloid sarcoma of breast (fig6)

Positive staining - normal
Positive staining - disease
Negative staining
  • Colonic epithelium, follicular lymphoma, Hodgkin’s lymphoma, lymphoepithelioma-like thymic carcinoma, primary effusion lymphoma, splenic marginal zone lymphoma
Additional references