CD Markers
CD43

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD43
General
  • Pan T cell marker important in T cell and neutrophil adhesion to endothelium
Terminology
  • Also called leukosialin, sialophorin
Pathophysiology
Clinical Features
  • Has defective expression in T cells of males with Wiskott-Aldrich syndrome (MIM 301000)
Uses by Pathologists
  • Pan T cell marker
  • Diagnosis of myeloid (granulocytic) sarcoma (J Clin Pathol 2005;58:211)
  • Classify subtypes of T cell lymphomas and low grade B cell lymphomas
  • Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J Surg Pathol 2002;26:76)
Micro Images

Images hosted on Pathout server:

Left: leukemia cutis; Right: MALT lymphoma of stomach



Images hosted on other servers:

Right: mantle cell lymphoma

Anaplastic large cell lymphoma


Anaplastic lymphoma: Left - breast (fig C); Middle - post transplant tumor of stomach (fig D); Right - AIDS associated


Left: CD4+/CD56+ hematodermic neoplasm / blastic NK lymphoma; Right: myeloid sarcoma of breast (fig6)

Positive Staining - Normal
Positive Staining - Disease
Negative Staining
  • Colonic epithelium, follicular lymphoma, Hodgkin’s lymphoma, lymphoepithelioma-like thymic carcinoma, primary effusion lymphoma, splenic marginal zone lymphoma
Additional References