CD Markers
CD44R

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD44v, CD44v9

Related topics: CD44
Cite this page: CD44R. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd44r.html. Accessed December 4th, 2016.
Definition / General
  • Heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells; upregulated in activated leukocytes
  • Also called CD44v, CD44v9
  • See CD44 (above) for more information
Pathophysiology
  • Transcripts for CD44 undergo complex alternative splicing, causing functionally distinct isoforms, whose nature has not yet been determined
  • Cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration
Uses by Pathologists
  • No significant clinical uses for pathologists
Positive Staining - Disease