CD Markers
CD44R


Topic Completed: 1 October 2013

Minor changes: 4 December 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: CD44v, CD44v9

Nat Pernick, M.D.
Page views in 2019: 76
Page views in 2020 to date: 44
Cite this page: Pernick N. CD44R. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd44r.html. Accessed August 13th, 2020.
Definition / general
  • Heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells; upregulated in activated leukocytes
  • Also called CD44v, CD44v9
  • See CD44 for more information
Pathophysiology
  • Transcripts for CD44 undergo complex alternative splicing, causing functionally distinct isoforms, whose nature has not yet been determined
  • Cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration
Uses by pathologists
  • No significant clinical uses for pathologists
Positive staining - disease
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