Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

CD Markers

CD45RB


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 11 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
=========================================================================

● CD45 isoform generated by alternative mRNA splicing of exon 5, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)

Physiology
=========================================================================

● CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
● CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
● CD45 isoforms, including CD45RB, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule
● Down regulated in memory cells

Diagrams
=========================================================================


CD45RB expression changes during germinal center reaction

Clinical features
=========================================================================

● Influx of CD4+, CD45RB high T cells is present in inflammatory bowel disease; may be important in pathogenesis as they produce more proinflammatory cytokines than CD4+ CD45RB low T cells (J Leukoc Biol 2004;75:1010)

Uses by pathologists
=========================================================================

● No significant clinical use by pathologists

Micro images
=========================================================================


Normal tonsil (B cells are positive)

Positive staining (normal)
=========================================================================

● Similar staining as CD45, except not expressed in Langerhans cells and some T cells
● B cells, most T cells, monocytes, macrophages, granulocytes (weak)

Positive staining (disease)
=========================================================================

● Most leukemias and lymphomas

Negative staining
=========================================================================

● Some T cells; Langerhans cells, platelets
● Plasma cell neoplasms, Reed-Sternberg cells, some lymphoblastic lymphomas, some anaplastic large cell lymphomas

End of CD Markers > CD45RB


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).