Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 11 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
● CD45 isoform generated by alternative mRNA splicing of exon 5, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)
● CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
● CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
● CD45 isoforms, including CD45RB, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule
● Down regulated in memory cells
CD45RB expression changes during germinal center reaction
● Influx of CD4+, CD45RB high T cells is present in inflammatory bowel disease; may be important in pathogenesis as they produce more proinflammatory cytokines than CD4+ CD45RB low T cells (J Leukoc Biol 2004;75:1010)
Uses by pathologists
● No significant clinical use by pathologists
Normal tonsil (B cells are positive)
Positive staining (normal)
● Similar staining as CD45, except not expressed in Langerhans cells and some T cells
● B cells, most T cells, monocytes, macrophages, granulocytes (weak)
Positive staining (disease)
● Most leukemias and lymphomas
● Some T cells; Langerhans cells, platelets
● Plasma cell neoplasms, Reed-Sternberg cells, some lymphoblastic lymphomas, some anaplastic large cell lymphomas
End of CD Markers > CD45RB
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