CD Markers
CD45RC

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD45RC[title]

Related topics: CD45, CD45RO, CD45RA, CD45RB

Cite this page: CD45RC. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd45rc.html. Accessed December 4th, 2016.
Definition / General
  • CD45 isoform generated by alternative mRNA splicing of exon 6, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)
  • Protein tyrosine phosphatase, receptor type C; PTPRC gene
  • CD45RC+ CD4+ cells and CD45RC- CD4+ T cells have different cytokine profiles (Th1-like and Th2-like respectively)
  • CD45RC expression divides human T cells into functionally distinct subsets that are imbalanced in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV); this may be a pre-existing immune abnormality involved in the etiology of AAV (PLoS One 2009;4:e5287)
  • References: OMIM #151460
Pathophysiology
  • CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
  • CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
  • CD45 isoforms, including CD45RC, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Thymocytes, monocytes and dendritic cells
  • High levels: B cells, NK and CD4+ T cells
  • Intermediate levels: CD8+ T cells
Negative Staining
  • Myeloid cells