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CD Markers

CD45RC


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 11 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● CD45 isoform generated by alternative mRNA splicing of exon 6, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)

Terminology
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● Protein tyrosine phosphatase, receptor type C; PTPRC gene
● CD45RC+ CD4+ cells and CD45RC- CD4+ T cells have different cytokine profiles (Th1-like and Th2-like respectively)

Physiology
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● CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
● CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
● CD45 isoforms, including CD45RC, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule

Clinical features
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● CD45RC expression divides human T cells into functionally distinct subsets that are imbalanced in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV); this may be a pre-existing immune abnormality involved in the etiology of AAV (PLoS One 2009;4:e5287)

Uses by pathologists
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● No significant clinical use by pathologists

Positive staining (normal)
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● Thymocytes, monocytes, dendritic cells
● High levels: B cells, NK, CD4+ T cells
● Intermediate levels: CD8+ T cells

Negative staining
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● Myeloid cells

Additional references
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MIM 151460

End of CD Markers > CD45RC


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