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CD Markers

CD45RO

Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 3 February 2011, last major update February 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Marker of activated T cells

Terminology
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● Also called UCHL1, although this is also an abbreviation for ubiquitin carboxyl-terminal esterase L1, a gene expressed in neurons, and whose mutations are associated with Parkinson's disease

Physiology
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● Most regulatory T cells in adults are CD45RO+; percentage increases with age (J Immunol 2010;184:4317)
● Ligand is CD22
● CD45RO+ T cells are more common than naïve T cells (CD45RA+) in inflammatory myopathies (Am J Pathol 1995;146:1178)

Clinical features
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● Low density of intratumoral CD45RO+ cells was poor prognostic factor for non-metastasized esophageal adenocarcinoma (BMC Cancer 2010;10:608)
● Increased CD45RO+ T cell infiltrate is present in atherosclerosis (Am J Pathol 1992;140:907), diffuse large B cell lymphoma, MALT lymphoma (Am J Pathol 1997;151:1353), Hashimoto’s thyroiditis-interfollicular infiltrate (J Clin Pathol 2004;57:1258), Kikuchi’s disease, molar pregnancy (J Clin Pathol 1999;52:888), ovarian carcinoma (Am J Pathol 1997;150:1723), primary cutaneous neoplasms (Am J Pathol 1993;142:1556), well nourished vs. malnourished infected children (Clin Exp Immunol 2001;126:461)
● CD4+ CD45RO+ T cells are a major latent viral reservoir in HIV+ individuals (Am J Pathol 1992;140:15)
● Increased percentage of CD45RO+ peripheral blood T cells in patients with preeclampsia (Am J Obstet Gynecol 2002;187:889) and psoriasis (Ann Univ Mariae Curie Sklodowska [Med] 2001;56:465)

Uses
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● T cell marker for diagnosis and classification of lymphoma
● Identify T cell subsets (i.e. memory T cells)

Micro images
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Normal lymph nodes

Spleen in autoimmune lymphoproliferative syndrome is CD45RO negative


CLL with prolymphocytic and Hodgkin’s lymphoma transformation and CD45RO+ infiltrating T cells (figure 3)


Hepatosplenic alpha-beta T cell lymphoma (figure C)


Multiple myeloma-plasma cell staining


NK/T cell lymphoma, nasal type (figure c)


NK-like T cell lymphoma of parotid gland of HIV+ man (figure 2B)

Positive staining (normal)
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● Memory and activated T cells, granulocytes, monocytes, macrophages, cortical thymocytes; some B cells

Positive staining (disease)
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● T cell lymphomas (75%), including angiocentric and angioimmunoblastic (Hum Pathol 2005;36:784), cutaneous T cell, hepatosplenic alpha-beta and gamma-delta, peripheral NOS (Am J Clin Pathol 2010;133:281)
● AML (25%), histiocytic sarcoma (Am J Surg Pathol 2004;28:1133)
● Myeloma (some, both on tumor cells and in infiltrate, J Clin Pathol 1998;51:432)
● Some plasma cell neoplasms
● Also Candida albicans (Am J Clin Pathol 2000;113:59)

Negative staining
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● B cells (most), NK cells
● B cell lymphoma (most), carcinoma, autoimmune lymphoproliferative syndrome (Am J Pathol 1998;153:1541)

End of CD Markers > CD45RO

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