CD Markers
CD45RO

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: UCHL1

Related topics: CD45, CD45RA, CD45RB, CD45RC

Definition / General
Pathophysiology
Uses by Pathologists
  • T cell marker for diagnosis and classification of lymphoma
  • Identify T cell subsets (i.e. memory T cells)
Micro Images

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Hepatosplenic alpha-beta T cell lymphoma (fig C)

Multiple myeloma-plasma cell staining


CLL with prolymphocytic and Hodgkin’s lymphoma
transformation and CD45RO+ infiltrating T cells (fig 3)


NK/T cell lymphoma, nasal type (figure C)

NK-like T cell lymphoma of parotid gland of HIV+ man (fig 2B)

Positive Staining - Normal
  • Memory and activated T cells, granulocytes, monocytes, macrophages and cortical thymocytes; some B cells
Positive Staining - Disease
Negative Staining
  • B cells (most), NK cells
  • B cell lymphoma (most), carcinoma and autoimmune lymphoproliferative syndrome (Am J Pathol 1998;153:1541)