CD Markers
CD48

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 December 2015, last major update December 2010

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD48
Definition / General
  • Activation associated cell surface glycoprotein active in lymphocytes
Terminology
  • Also called B-lymphocyte activation marker Blast-1
Pathophysiology
  • Glycosyl phosphatidylinositol (GPI) anchored surface molecule that mediates T cell activation by binding to CD2 ( J Immunol 2009;182:7672)
  • Induces numerous effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils, partly based on its interaction with 2B4 / CD244 (Int J Biochem Cell Biol 2011;43:25)
  • Regulates NK cell effector function (Blood 2006;107:3181)
Clinical Features
Uses by Pathologists
  • No significant clinical uses for pathologists
Positive Staining - Normal
  • Lymphocytes, monocytes, granulocytes (weak)
Negative Staining
  • Platelets, fibroblasts, epithelium, endothelium; usually dendritic cells (J Immunol 2005;175:3690)
Additional References