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CD Markers

CD48


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 24 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Activation associated cell surface glycoprotein active in lymphocytes

Terminology
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● Also called B-lymphocyte activation marker Blast-1

Physiology
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● Glycosyl phosphatidylinositol (GPI) anchored surface molecule that mediates T cell activation by binding to CD2 (J Immunol 2009;182:7672)
● Induces numerous effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils, partly based on its interaction with 2B4 / CD244 (Int J Biochem Cell Biol 2011;43:25)
● Regulates NK cell effector function (Blood 2006;107:3181)

Clinical features
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● Mast cell response to M. tuberculosis is mediated by CD48 (J Immunol 2003;170:5590)

Uses for pathologists
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● No significant clinical uses for pathologists

Positive stains - normal
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● Lymphocytes, monocytes, granulocytes (weak)

Negative stains
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● Platelets, fibroblasts, epithelium, endothelium; usually dendritic cells (J Immunol 2005;175:3690)

Additional references
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MIM 109530

End of CD Markers > CD48


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