CD Markers
CD49a

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2016, last major update December 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD49

Related:   CD49bCD49cCD49d


General
  • Integrin alpha 1 chain, which combines with beta1 subunit (CD29) to form a receptor for collagen and laminin
  • Also called very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain and ITGA1
  • Mesenchymal stem cells are selected from bone marrow by CD49+ with flow cytometry (Br J Haematol 2003;122:506, J Mol Histol 2007;38:449)
  • References: OMIM #192968
Pathophysiology
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain; a given chain may combine with multiple partners resulting in different integrins
  • Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts and platelets
  • CD49a combines with beta1 subunit (CD29) to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
  • CD49a contributes to beta cell functions important for pancreatic islet morphogenesis and glucose homeostasis (J Biol Chem 2004;279:53762)
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Activated B and T cells, monocytes, fibroblasts, platelets, endothelial cells and smooth muscle cells