Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 24 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
● Integrin alpha 1 chain, which combines with beta1 subunit (CD29) to form a receptor for collagen and laminin
● Also called very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain, ITGA1
● Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain; a given chain may combine with multiple partners resulting in different integrins
● Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts and platelets
● CD49a combines with beta1 subunit (CD29) to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
● CD49a contributes to beta cell functions important for pancreatic islet morphogenesis and glucose homeostasis (J Biol Chem 2004;279:53762)
● Mesenchymal stem cells are selected from bone marrow by CD49+ with flow cytometry (Br J Haematol 2003;122:506, J Mol Histol 2007;38:449)
Uses for pathologists
● No significant clinical use by pathologists
Positive stains - normal
● Activated B and T cells, monocytes, fibroblasts, platelets, endothelial cells, smooth muscle cells
● MIM 192968
End of CD Markers > CD49a
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