Home   Chapter Home   Jobs   Conferences   Fellowships   Books


CD Markers


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 24 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.


● Integrin alpha 1 chain, which combines with beta1 subunit (CD29) to form a receptor for collagen and laminin


● Also called very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain, ITGA1


● Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain; a given chain may combine with multiple partners resulting in different integrins
● Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts and platelets
● CD49a combines with beta1 subunit (CD29) to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
● CD49a contributes to beta cell functions important for pancreatic islet morphogenesis and glucose homeostasis (J Biol Chem 2004;279:53762)

Clinical features

● Mesenchymal stem cells are selected from bone marrow by CD49+ with flow cytometry (Br J Haematol 2003;122:506, J Mol Histol 2007;38:449)

Uses for pathologists

● No significant clinical use by pathologists

Positive stains - normal

● Activated B and T cells, monocytes, fibroblasts, platelets, endothelial cells, smooth muscle cells

Additional references

MIM 192968

End of CD Markers > CD49a

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).