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CD Markers

CD49a


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 24 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Integrin alpha 1 chain, which combines with beta1 subunit (CD29) to form a receptor for collagen and laminin

Terminology
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● Also called very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain, ITGA1

Physiology
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● Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain; a given chain may combine with multiple partners resulting in different integrins
● Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts and platelets
● CD49a combines with beta1 subunit (CD29) to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
● CD49a contributes to beta cell functions important for pancreatic islet morphogenesis and glucose homeostasis (J Biol Chem 2004;279:53762)

Clinical features
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● Mesenchymal stem cells are selected from bone marrow by CD49+ with flow cytometry (Br J Haematol 2003;122:506, J Mol Histol 2007;38:449)

Uses for pathologists
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● No significant clinical use by pathologists

Positive stains - normal
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● Activated B and T cells, monocytes, fibroblasts, platelets, endothelial cells, smooth muscle cells

Additional references
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MIM 192968

End of CD Markers > CD49a


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