CD Markers
CD49b

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2016, last major update December 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD49

Related:   CD49aCD49cCD49d


General
Pathophysiology
  • Receptor for laminin, collagen, fibronectin and E-cadherin
  • Responsible for platelet adhesion to subendothelial tissue; after endothelial damage, circulating platelets via platelet surface GP Ib-IX-V complex contact subendothelial vWF bound to collagen; this initial contact slows down the platelets, allowing platelet CD49b to bind to endothelial collagen; this stops the platelets, and contributes to their activation and aggregation (Blood 2005;105:1986)
  • CD49b mediates disassembly of actin cytoskeleton stress fibers and focal adhesions, leading to block of endothelial cell migration and angiogenesis (J Cell Biol 2004;166:97)
  • May be a immunodominant minor histocompatibility antigen (Blood 1998;92:2169)
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Platelets, activated B & T cells, monocytes, megakaryocytes and NK cells (most)
Videos


Platelet adhesion and aggregation