CD Markers

Topic Completed: 1 December 2010

Minor changes: 4 December 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: CD49

Related:   CD49aCD49cCD49d

Nat Pernick, M.D.
Page views in 2019: 78
Page views in 2020 to date: 67
Cite this page: Pernick N. CD49b. website. Accessed August 7th, 2020.
Definition / general
  • Receptor for laminin, collagen, fibronectin and E-cadherin
  • Responsible for platelet adhesion to subendothelial tissue; after endothelial damage, circulating platelets via platelet surface GP Ib-IX-V complex contact subendothelial vWF bound to collagen; this initial contact slows down the platelets, allowing platelet CD49b to bind to endothelial collagen; this stops the platelets, and contributes to their activation and aggregation (Blood 2005;105:1986)
  • CD49b mediates disassembly of actin cytoskeleton stress fibers and focal adhesions, leading to block of endothelial cell migration and angiogenesis (J Cell Biol 2004;166:97)
  • May be a immunodominant minor histocompatibility antigen (Blood 1998;92:2169)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Platelets, activated B & T cells, monocytes, megakaryocytes and NK cells (most)

Platelet adhesion and aggregation

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