CD Markers
CD49b


Topic Completed: 1 December 2010

Minor changes: 4 December 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: CD49

Related:   CD49aCD49cCD49d

Nat Pernick, M.D.
Page views in 2019: 78
Page views in 2020 to date: 39
Cite this page: Pernick N. CD49b. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd49b.html. Accessed May 28th, 2020.
Definition / general
Pathophysiology
  • Receptor for laminin, collagen, fibronectin and E-cadherin
  • Responsible for platelet adhesion to subendothelial tissue; after endothelial damage, circulating platelets via platelet surface GP Ib-IX-V complex contact subendothelial vWF bound to collagen; this initial contact slows down the platelets, allowing platelet CD49b to bind to endothelial collagen; this stops the platelets, and contributes to their activation and aggregation (Blood 2005;105:1986)
  • CD49b mediates disassembly of actin cytoskeleton stress fibers and focal adhesions, leading to block of endothelial cell migration and angiogenesis (J Cell Biol 2004;166:97)
  • May be a immunodominant minor histocompatibility antigen (Blood 1998;92:2169)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Platelets, activated B & T cells, monocytes, megakaryocytes and NK cells (most)
Videos


Platelet adhesion and aggregation



Back to top