CD Markers
CD49c


Topic Completed: 1 December 2010

Revised: 4 December 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: CD49

Related:   CD49aCD49bCD49d

Nat Pernick, M.D.
Page views in 2018: 16
Page views in 2019 to date: 10
Cite this page: Pernick, N. CD49c. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd49c.html. Accessed December 6th, 2019.
Definition / general
  • Major receptor for laminin; also a receptor for collagen, fibronectin and thrombospondin
  • Also called very late antigen (VLA) alpha 3 chain (VLA-3), ITGA3
  • Common integrin is alpha3beta1, which is CD49c and CD29
  • Has two isoforms produced by alternate splicing: alpha-3A and alpha-3B
  • Tumor cell alpha3beta1 binds to exposed basement membrane on pulmonary vessels to cause tumor cell arrest and early colony formation (J Cell Biol 2004;164:935)
  • May play a role in peritoneal dissemination of gastric carcinoma (Cancer Res 2004;64:6065)
  • May mediate invasion of melanoma cells (Clin Exp Metastasis 2002;19:127)
  • References: OMIM #605025
Pathophysiology
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Negative staining
  • Platelets
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