Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

CD Markers

CD49c


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 25 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
=========================================================================

● Major receptor for laminin; also a receptor for collagen, fibronectin and thrombospondin

Terminology
=========================================================================

● Also called very late antigen (VLA) alpha 3 chain (VLA-3), ITGA3
● Common integrin is alpha3beta1, which is CD49c and CD29
● Has two isoforms produced by alternate splicing: alpha-3A and alpha-3B

Physiology
=========================================================================

● Binds to laminin 10/11, the major basement membrane component on many adult tissues, suggesting that it has a central role in adhesion of epithelial cells with basement membrane (J Biochem (Tokyo) 2003;134:497)
● Mediates angiogenesis through both repression (Am J Pathol 2010;177:1534, and promotion (J Cell Sci 2009;122:1778)

Clinical features
=========================================================================

● Tumor cell alpha3beta1 binds to exposed basement membrane on pulmonary vessels to cause tumor cell arrest and early colony formation (J Cell Biol 2004;164:935)
● May play a role in peritoneal dissemination of gastric carcinoma (Cancer Res 2004;64:6065)
● May mediate invasion of melanoma cells (Clin Exp Metastasis 2002;19:127)

Uses for pathologists
=========================================================================

● No significant clinical use by pathologists

Micro images
=========================================================================


Anterior lens of eye (figure 1b)

   

Skin basement membrane staining

Positive stains - normal
=========================================================================

● B & T cells, most nonhematopoietic cells; lens capsule (Eye 2003;17:473)

Negative stains
=========================================================================

● Platelets

Additional references
=========================================================================

MIM 605025

End of CD Markers > CD49c


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).