CD Markers
CD49c

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2016, last major update December 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD49

Related:   CD49aCD49bCD49d


Definition / General
  • Major receptor for laminin; also a receptor for collagen, fibronectin and thrombospondin
  • Also called very late antigen (VLA) alpha 3 chain (VLA-3), ITGA3
  • Common integrin is alpha3beta1, which is CD49c and CD29
  • Has two isoforms produced by alternate splicing: alpha-3A and alpha-3B
  • Tumor cell alpha3beta1 binds to exposed basement membrane on pulmonary vessels to cause tumor cell arrest and early colony formation (J Cell Biol 2004;164:935)
  • May play a role in peritoneal dissemination of gastric carcinoma (Cancer Res 2004;64:6065)
  • May mediate invasion of melanoma cells (Clin Exp Metastasis 2002;19:127)
  • References: OMIM #605025
Pathophysiology
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

Image hosted on Nature.com:

Anterior lens of eye (figure 1b)

Positive Staining - Normal
Negative Staining
  • Platelets