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CD Markers

CD49e


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 25 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Fibronectin and fibrinogen receptor

Terminology
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● Also called very late antigen (VLA) alpha 5 chain (VLA5), ITGA5, fibronectin receptor (FNRA)

Physiology
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● Recognizes the sequence R-G-D in fibronectin and fibrinogen, mediating its adhesion function

Clinical features
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● Important in wound reepithelialization (Larjava: Keratinocyte Interactions with Fibronectin during Wound Healing, NIH)
● Weakening of tumor cell adhesion strength, controlled by alpha5beta1, may mediate tumor cell motility (Mol Biol Cell 2005;16:51)
● The arginine-glycine-aspartic acid (RGD) sequence present on HIV Tat protein mediates vascular cell migration and invasion by binding to the alpha5beta1 and alphavbeta3 integrins, promotes angiogenesis and Kaposi's sarcoma (Blood 1999;94:663)
● Persistently reduced expression of blood monocyte CD49e is an adverse prognostic marker in HIV (AIDS 2009;23:2247)

Uses for pathologists
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● No significant clinical use by pathologists

Positive stains - normal
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● T cells, early and activated B cells, platelets, monocytes, neutrophils

Micro images
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Immunofluorescence, contributed by Dr. Vincent Achard, France
Left: peripheral blood monocytes and platelets (green is positive); right: negative control


Additional references
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MIM 135620

End of CD Markers > CD49e


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