Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 25 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
● Fibronectin and fibrinogen receptor
● Also called very late antigen (VLA) alpha 5 chain (VLA5), ITGA5, fibronectin receptor (FNRA)
● Recognizes the sequence R-G-D in fibronectin and fibrinogen, mediating its adhesion function
● Important in wound reepithelialization (Larjava: Keratinocyte Interactions with Fibronectin during Wound Healing, NIH)
● Weakening of tumor cell adhesion strength, controlled by alpha5beta1, may mediate tumor cell motility (Mol Biol Cell 2005;16:51)
● The arginine-glycine-aspartic acid (RGD) sequence present on HIV Tat protein mediates vascular cell migration and invasion by binding to the alpha5beta1 and alphavbeta3 integrins, promotes angiogenesis and Kaposi's sarcoma (Blood 1999;94:663)
● Persistently reduced expression of blood monocyte CD49e is an adverse prognostic marker in HIV (AIDS 2009;23:2247)
Uses for pathologists
● No significant clinical use by pathologists
Positive stains - normal
● T cells, early and activated B cells, platelets, monocytes, neutrophils
Immunofluorescence, contributed by Dr. Vincent Achard, France
Left: peripheral blood monocytes and platelets (green is positive); right: negative control
● MIM 135620
End of CD Markers > CD49e
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).