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CD Markers

CD49f


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 25 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Forms laminin and thrombospondin receptors

Terminology
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● Also called very late antigen (VLA) alpha 6 chain (VLA6), ITGA6

Physiology
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● Forms laminin receptor on platelets (with CD29 / alpha6beta1) and on epithelial cells (with CD104 / alpha6beta4); alpha6beta1 is also part of the thrombospondin receptor (J Biol Chem 2003;278:40679)
● Important for formation of hemidesmosomes on stratified squamous and transitional epithelia

Clinical features
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● Commonly overexpressed in pre B-ALL; may be useful marker to detect minimal residual disease (Cytometry B Clin Cytom 2009;76:150)
● Alpha6beta1 is expressed on pancreatic cancer cells during invasion and metastasis formation (BMC Cell Biol 2006;7:8)
● In junctional epidermolysis bullosa with pyloric atresia, patients have antibodies to alpha6beta4 (J Clin Invest 1997;99:2826)
● Epitope within alpha6 protein may be site of binding of antibodies in oral pemphigoid (J Immunol 2006;176:1968)

Uses for pathologists
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● No significant clinical use by pathologists

Positive stains - normal
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● Epithelial cells, memory T cells, monocytes, platelets, megakaryocytes, thymocytes

Additional references
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MIM 147556

End of CD Markers > CD49f


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