CD Markers - CD49f

Home Chapter Home Jobs Conferences Fellowships Books

CD Markers

CD49f

Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 25 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
=========================================================================

● Forms laminin and thrombospondin receptors

Terminology
=========================================================================

● Also called very late antigen (VLA) alpha 6 chain (VLA6), ITGA6

Physiology
=========================================================================

● Forms laminin receptor on platelets (with CD29 / alpha6beta1) and on epithelial cells (with CD104 / alpha6beta4); alpha6beta1 is also part of the thrombospondin receptor (J Biol Chem 2003;278:40679)
● Important for formation of hemidesmosomes on stratified squamous and transitional epithelia

Clinical features
=========================================================================

● Commonly overexpressed in pre B-ALL; may be useful marker to detect minimal residual disease (Cytometry B Clin Cytom 2009;76:150)
● Alpha6beta1 is expressed on pancreatic cancer cells during invasion and metastasis formation (BMC Cell Biol 2006;7:8)
● In junctional epidermolysis bullosa with pyloric atresia, patients have antibodies to alpha6beta4 (J Clin Invest 1997;99:2826)
● Epitope within alpha6 protein may be site of binding of antibodies in oral pemphigoid (J Immunol 2006;176:1968)

Uses for pathologists
=========================================================================

● No significant clinical use by pathologists

Positive stains - normal
=========================================================================

● Epithelial cells, memory T cells, monocytes, platelets, megakaryocytes, thymocytes

Additional references
=========================================================================

● MIM 147556

End of CD Markers > CD49f

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).