CD Markers
CD51

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD51
Definition / General
  • Also called integrin alpha chain V or vitronectin receptor-alpha chain
  • Integrins are membrane receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organization, cell proliferation, cell survival and differentiation
  • Integrins are composed of an alpha chain and a beta chain
  • Alpha-V integrins are a subset of integrins with a common alpha-V subunit combined with beta subunits 1, 3, 5, 6 or 8
  • The beta chain of the vitronectin receptor is CD61
  • Most alpha-V integrins recognize the RGD (Arg-Gly-Asp) sequence in various ligands such as vitronectin, fibronectin, osteopontin, bone sialoprotein, thrombospondin, fibrinogen, von Willebrand factor, tenascin or agrin
  • Alpha V beta 3 integrin may mediate melanoma progression (Oncogene 2005;24:4710)
  • CD51 on some dendritic cells serves as adenovirus receptor (J Leukoc Biol 2006;79:1271)
  • OMIM #193210
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
Positive Staining - Disease
Negative Staining