CD Markers
CD52

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD52[title]
Cite this page: CD52. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd52.html. Accessed December 11th, 2016.
Definition / General
  • Also called Campath-1 and epididymal secretory protein E5
  • CD52 antibodies are lytic for target cells, both with human complement and via antibody dependent cellular cytotoxicity
  • References: OMIM #114280
Uses by Pathologists
Micro Images

Images hosted on other servers:

Fig 1A/B: normal tonsil shows lymphocytic staining, but there is no staining of connective tissue or vessels;
C: follicular lymphoma is CD52+; D: Reed-Sternberg cells (arrows) are CD52-


Fig 2A/B: SLL/CLL is CD52+; C: anaplastic lymphoma is CD52+; D: adult T cell leukemia/lymphoma is CD52+

Positive Staining - Normal
  • Thymocytes, lymphocytes, monocytes / macrophages, eosinophils, mast cells (Clin Lymphoma Myeloma 2006;6:478) and epithelial cells lining the male reproductive tract
Positive Staining - Disease
Negative Staining
  • Neutrophils, Langerhans cells (normal), lymphocytes in paroxysmal nocturnal hemaglobinuria and Reed-Sternberg cells in Hodgkin’s lymphoma